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    CONFOCAL IMAGING METHODS AND APPARATUS
    1.
    发明申请
    CONFOCAL IMAGING METHODS AND APPARATUS 有权
    协同成像方法和装置

    公开(公告)号：US20150069267A1

    公开(公告)日：2015-03-12

    申请号：US14489727

    申请日：2014-09-18

    Applicant: Illumina, Inc.

    Inventor： Wenyi Feng ,  Theofilos Kotseroglou ,  Mark Wang ,  Alexander Triener ,  Diping Che ,  Robert Kain

    IPC: G01N21/64

    CPC classification number: G01N21/6456 ,  G01N21/6428 ,  G01N21/6452 ,  G01N21/6458 ,  G01N2021/6421 ,  G02B21/0032 ,  G02B21/004

    Abstract: The invention provides imaging apparatus and methods useful for obtaining a high resolution image of a sample at rapid scan rates. A rectangular detector array having a horizontal dimension that is longer than the vertical dimension can be used along with imaging optics positioned to direct a rectangular image of a portion of a sample to the rectangular detector array. A scanning device can be configured to scan the sample in a scan-axis dimension, wherein the vertical dimension for the rectangular detector array and the shorter of the two rectangular dimensions for the image are in the scan-axis dimension, and wherein the vertical dimension for the rectangular detector array is short enough to achieve confocality in a single axis.

    Abstract translation: 本发明提供了用于以快速扫描速率获得样品的高分辨率图像的成像装置和方法。 具有比垂直尺寸长的水平尺寸的矩形检测器阵列可以与定位成将样本的一部分的矩形图像引导到矩形检测器阵列的成像光学元件一起使用。 扫描装置可以被配置成以扫描轴尺寸扫描样本，其中矩形检测器阵列的垂直尺寸和图像的两个矩形尺寸中的较短的尺寸在扫描轴尺寸上，并且其中垂直尺寸 因为矩形检测器阵列足够短以在单个轴上实现共焦。

    Assay instrument for detecting optical signals from samples having a controlled optics adjustment system based on the priority statuses of the samples
    2.
    发明授权
    Assay instrument for detecting optical signals from samples having a controlled optics adjustment system based on the priority statuses of the samples 有权
    用于根据样品的优先级状态从具有受控光学调节系统的样品检测光信号的测定仪器

    公开(公告)号：US09139875B2

    公开(公告)日：2015-09-22

    申请号：US14263746

    申请日：2014-04-28

    Applicant: ILLUMINA, INC.

    Inventor： Alexander Triener ,  Erik Allegoren ,  Wenyi Feng ,  Dale Buermann ,  Erik Olson ,  James Osmus

    IPC: C12Q1/68 ,  G01N21/64

    CPC classification number: C12Q1/6874 ,  C12Q1/6837 ,  G01N21/6428 ,  G01N21/645 ,  G01N21/6456

    Abstract: An optical system configured to detect optical signals during imaging sessions. The optical system includes an objective lens that has a collecting end that is positioned proximate to a sample and configured to receive optical signals therefrom. The optical system also includes a removable path compensator that is configured to be located at an imaging position between the collecting end of the objective lens and the sample. The path compensator adjusts an optical path of the light emissions when in the imaging position. Also, the optical system includes a transfer device that is configured to move the path compensator. The transfer device locates the path compensator at the imaging position for a first imaging session and removes the path compensator from the imaging position for a second imaging session.

    Abstract translation: 一种配置成在成像会话期间检测光信号的光学系统。 光学系统包括物镜，该物镜具有位于样品附近并被配置为从其接收光信号的收集端。 光学系统还包括被配置为位于物镜的收集端和样品之间的成像位置处的可移除路径补偿器。 路径补偿器在成像位置调整光发射的光路。 此外，光学系统包括被配置为移动路径补偿器的传送装置。 传送装置将路径补偿器定位在用于第一成像会话的成像位置处，并从第二成像会话的成像位置移除路径补偿器。

    Assay instrument for detecting optical signals from samples
    3.
    发明授权
    Assay instrument for detecting optical signals from samples 有权
    用于检测样品光学信号的测定仪器

    公开(公告)号：US08748789B2

    公开(公告)日：2014-06-10

    申请号：US13905633

    申请日：2013-05-30

    Applicant: Illumina, Inc.

    Inventor： Alexander Triener ,  Erik Allegoren ,  Wenyi Feng ,  Dale Buermann ,  Erik Olson ,  James Osmus

    IPC: G02B7/04

    CPC classification number: C12Q1/6874 ,  C12Q1/6837 ,  G01N21/6428 ,  G01N21/645 ,  G01N21/6456

    Abstract: An optical system configured to detect optical signals during imaging sessions. The optical system includes an objective lens that has a collecting end that is positioned proximate to a sample and configured to receive optical signals therefrom. The optical system also includes a removable path compensator that is configured to be located at an imaging position between the collecting end of the objective lens and the sample. The path compensator adjusts an optical path of the light emissions when in the imaging position. Also, the optical system includes a transfer device that is configured to move the path compensator. The transfer device locates the path compensator at the imaging position for a first imaging session and removes the path compensator from the imaging position for a second imaging session.

    Abstract translation: 一种配置成在成像会话期间检测光信号的光学系统。 光学系统包括物镜，该物镜具有位于样品附近并被配置为从其接收光信号的收集端。 光学系统还包括被配置为位于物镜的收集端和样品之间的成像位置处的可移除路径补偿器。 路径补偿器在成像位置调整光发射的光路。 此外，光学系统包括被配置为移动路径补偿器的传送装置。 传送装置将路径补偿器定位在用于第一成像会话的成像位置处，并从第二成像会话的成像位置移除路径补偿器。

    SYSTEMS, METHODS, AND APPARATUSES FOR DETECTING OPTICAL SIGNALS FROM A SAMPLE
    4.
    发明申请
    SYSTEMS, METHODS, AND APPARATUSES FOR DETECTING OPTICAL SIGNALS FROM A SAMPLE 有权
    用于从样品中检测光信号的系统，方法和装置

    公开(公告)号：US20130261028A1

    公开(公告)日：2013-10-03

    申请号：US13905633

    申请日：2013-05-30

    Applicant: ILLUMINA, INC.

    Inventor： Alexander Triener ,  Erik Allegoren ,  Wenyi Feng ,  Dale Buermann ,  Erik Olson ,  James Osmus

    IPC: G01N21/64

    CPC classification number: C12Q1/6874 ,  C12Q1/6837 ,  G01N21/6428 ,  G01N21/645 ,  G01N21/6456

    Abstract: An optical system configured to detect optical signals during imaging sessions. The optical system includes an objective lens that has a collecting end that is positioned proximate to a sample and configured to receive optical signals therefrom. The optical system also includes a removable path compensator that is configured to be located at an imaging position between the collecting end of the objective lens and the sample. The path compensator adjusts an optical path of the light emissions when in the imaging position. Also, the optical system includes a transfer device that is configured to move the path compensator. The transfer device locates the path compensator at the imaging position for a first imaging session and removes the path compensator from the imaging position for a second imaging session.

    Abstract translation: 一种配置成在成像会话期间检测光信号的光学系统。 光学系统包括物镜，该物镜具有位于样品附近并被配置为从其接收光信号的收集端。 光学系统还包括被配置为位于物镜的收集端和样品之间的成像位置处的可移除路径补偿器。 路径补偿器在成像位置调整光发射的光路。 此外，光学系统包括被配置为移动路径补偿器的传送装置。 传送装置将路径补偿器定位在用于第一成像会话的成像位置处，并从第二成像会话的成像位置移除路径补偿器。

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