公开(公告)号：US20190225986A1

公开(公告)日：2019-07-25

申请号：US16206258

申请日：2018-11-30

Applicant: ID PHARMA CO., LTD.

Inventor： Katsuyuki Mitomo ,  Makoto Inoue ,  Hitoshi Iwasaki ,  Mamoru Hasegawa ,  Eric W. Alton ,  Uta Griesenbach

IPC: C12N15/86 ,  A61K38/17 ,  C07K14/47 ,  C12N5/071 ,  A61K9/00 ,  A61K38/16 ,  C12N7/00

Abstract: The present inventors successfully introduced genes into stem cells of airway epithelial tissues using simian immunodeficiency virus vectors pseudotyped with F and HN, which are envelope glycoproteins of Sendai virus. Gene transfer into airway epithelial tissue stem cells using a vector of the present invention is useful for gene therapy of genetic respiratory diseases such as cystic fibrosis. Furthermore, it is possible to select respiratory organs such as the lungs as production tissues for providing proteins that are deficient due to genetic diseases.

公开(公告)号：US20160281109A1

公开(公告)日：2016-09-29

申请号：US15179492

申请日：2016-06-10

Applicant: ID PHARMA CO., LTD.

Inventor： Katsuyuki Mitomo ,  Makoto Inoue ,  Hitoshi Iwasaki ,  Mamoru Hasegawa ,  Eric W. Alton ,  Uta Griesenbach

IPC: C12N15/86 ,  A61K38/17

CPC classification number: C12N15/86 ,  A61K9/0043 ,  A61K38/162 ,  A61K38/1709 ,  A61K38/177 ,  A61K48/00 ,  C07K14/4712 ,  C12N5/0688 ,  C12N7/00 ,  C12N2510/00 ,  C12N2740/15033 ,  C12N2740/15043 ,  C12N2740/15045 ,  C12N2810/6072 ,  C12N2810/609

Abstract: The present inventors successfully introduced genes into stem cells of airway epithelial tissues using simian immunodeficiency virus vectors pseudotyped with F and HN, which are envelope glycoproteins of Sendai virus. Gene transfer into airway epithelial tissue stem cells using a vector of the present invention is useful for gene therapy of genetic respiratory diseases such as cystic fibrosis. Furthermore, it is possible to select respiratory organs such as the lungs as production tissues for providing proteins that are deficient due to genetic diseases.