公开(公告)号：US06372844B1

公开(公告)日：2002-04-16

申请号：US09536677

申请日：2000-03-28

Applicant: Hosei Shinoda ,  Yukiko Asou ,  Hiroaki Tamatani

Inventor： Hosei Shinoda ,  Yukiko Asou ,  Hiroaki Tamatani

IPC: C08L5108

CPC classification number: C08L67/02 ,  C08L69/00 ,  C08L101/00 ,  C08L2666/20

Abstract: There are here disclosed a resin composition comprising a block or a graft copolymer (A) having a polyamino acid as a hydrophilic segment (a-1), and a degradable polymer as a hydrophobic segment (a-2), and a resin (B); and a method of accelerating the hydrolysis of a resin and inhibiting the heat deterioration thereof by mixing this copolymer (A) with the resin (B).

Abstract translation: 这里公开了包含具有聚氨基酸作为亲水性链段（a-1）的嵌段或接枝共聚物（A）和作为疏水链段（a-2）的可降解聚合物和树脂（B）的树脂组合物 ）; 和通过将该共聚物（A）与树脂（B）混合来加速树脂的水解并抑制其热劣化的方法。

公开(公告)号：US06419951B1

公开(公告)日：2002-07-16

申请号：US09985874

申请日：2001-11-06

Applicant: Hosei Shinoda ,  Yukiko Asou ,  Hiroaki Tamatani

Inventor： Hosei Shinoda ,  Yukiko Asou ,  Hiroaki Tamatani

IPC: A61K952

CPC classification number: C08G73/1092 ,  A61K9/1641 ,  C08G73/16

Abstract: A sustained releasing drug which includes an effective component and a copolymer having a weight-average molecular weight of 1,000 to 100,000 which comprises, as repeating structure units, both of a succinimide unit represented by the structural formula (1) and a hydroxycarboxylic acid unit represented by the structural formula (2) wherein R is a methyl group or a hydrogen atom, and a process for preparing a copolymer which comprises a polymerization step of heating a mixture of aspartic acid and a cyclic ester compound.

Abstract translation: 一种持续释放药物，其包含有效成分和重均分子量为1,000〜100,000的共聚物，其包含作为重复结构单元的由结构式（1）表示的琥珀酰亚胺单元和表示的结构式（1）所示的羟基羧酸单元 通过其中R是甲基或氢原子的结构式（2），以及包括加热天冬氨酸和环状酯化合物的混合物的聚合步骤的共聚物的制备方法。

公开(公告)号：US06372880B1

公开(公告)日：2002-04-16

申请号：US09219452

申请日：1998-12-23

Applicant: Hosei Shinoda ,  Yukiko Asou ,  Hiroaki Tamatani

Inventor： Hosei Shinoda ,  Yukiko Asou ,  Hiroaki Tamatani

IPC: C08G6344

CPC classification number: C08G73/1092 ,  A61K9/1641 ,  C08G73/16

Abstract: A copolymer having a weight-average molecular weight of 1,000 to 100,000 which comprises, as repeating structure units, both of a succinimide unit represented by the structural formula (1) and a hydroxycarboxylic acid unit represented by the structural formula (2) wherein R is a methyl group or a hydrogen atom, and a process for preparing a copolymer which comprises a polymerization step of heating a mixture of aspartic acid and a cyclic ester compound.

Abstract translation: 一种重均分子量为1,000〜100,000的共聚物，其包含由结构式（1）表示的琥珀酰亚胺单元和由结构式（2）表示的羟基羧酸单元作为重复结构单元，其中R为 甲基或氢原子，以及制备共聚物的方法，其包括加热天冬氨酸和环状酯化合物的混合物的聚合步骤。

公开(公告)号：US06342241B1

公开(公告)日：2002-01-29

申请号：US09488707

申请日：2000-01-21

Applicant: Yukiko Asou ,  Hosei Shinoda ,  Hiroaki Tamatani

Inventor： Yukiko Asou ,  Hosei Shinoda ,  Hiroaki Tamatani

IPC: A61F1300

CPC classification number: A61K47/34 ,  A61K9/0024

Abstract: A medical composition is here disclosed which comprises a hydroxy acid-based oligomer (A) and a drug (B), wherein the hydroxy acid-based oligomer (A) is an oligomer in which the carboxylic acid-terminals are at least partially esterified, and the oligomer (A) has a function of becoming pH 5 to 8 when administered into an organism, and the oligomer (A) shows fluidity at 25° C. This composition sustainedly releases the drug (B) to deliver it into an organism by a syringe or the like, and scarcely gives rise to irritation, inflammation or the like.

Abstract translation: 这里公开了包含羟基酸类低聚物（A）和药物（B）的医药组合物，其中羟基酸类低聚物（A）是其中羧酸末端至少部分酯化的低聚物， 并且低聚物（A）在施用于生物体时具有变为pH5〜8的功能，低聚物（A）在25℃下显示出流动性。该组合物持续释放药物（B），以通过 注射器等，几乎不引起刺激，炎症等。