公开(公告)号：US20150208957A1

公开(公告)日：2015-07-30

申请号：US14327553

申请日：2014-07-09

Applicant: Hong Kong Applied Science and Technology Research Institute Co., Ltd.

Inventor： Chun ZHANG ,  Ka Cheung KWOK ,  Lydia Lap Wai LEUNG

IPC: A61B5/1455 ,  A61B5/05 ,  A61B5/00 ,  G01N21/63

CPC classification number: A61B5/1455 ,  A61B5/0075 ,  G01J3/0202 ,  G01J3/0216 ,  G01J3/0227 ,  G01J3/0237 ,  G01J3/06 ,  G01J3/44 ,  G01N21/63 ,  G01N21/65 ,  G01N2201/06113

Abstract: A transmission-reflectance swappable Raman device and a method thereof are disclosed. The excitation light is selectively directed to the sample in one direction for generating the transmission Raman signal in transmission mode or in another direction for generating the reflectance Raman signal in reflectance mode. The content of an analyte in a sample can be determined by analyzing transmission and reflectance Raman signal.

Abstract translation: 公开了一种透射反射可交换拉曼装置及其方法。 激发光在一个方向上选择性地导向样品，以在透射模式或另一方向上产生透射拉曼信号，以在反射模式下产生反射拉曼信号。 可以通过分析透射和反射拉曼信号来确定样品中分析物的含量。

公开(公告)号：US20160354015A1

公开(公告)日：2016-12-08

申请号：US14729075

申请日：2015-06-03

Applicant: Hong Kong Applied Science and Technology Research Institute Co. Ltd.

Inventor： Chun ZHANG ,  Tsz Ho LAU ,  Yuk Cheung CHAN ,  Wei Mong TSANG

IPC: A61B5/1455 ,  A61B5/107 ,  A61B5/05 ,  A61B5/1495 ,  A61B8/08 ,  A61B5/145 ,  A61B5/00

CPC classification number: A61B5/1455 ,  A61B5/0075 ,  A61B5/0507 ,  A61B5/1075 ,  A61B5/1076 ,  A61B5/1079 ,  A61B5/14532 ,  A61B5/1495 ,  A61B5/7225 ,  A61B5/7246 ,  A61B5/7275 ,  A61B5/7278 ,  A61B2562/0238

Abstract: The present invention discloses a non-invasive method of measuring skin thickness and blood glucose concentration of a subject by a Raman system. The advantage of the present invention is that a single Raman spectrum is used to measure both the skin thickness and glucose concentration. The skin thickness and Raman intensity retrieved from the same Raman spectrum are both utilized to yield a more accurate blood glucose concentration. The present invention also discloses a Raman system for measuring physiological data of a subject. It comprises a Raman spectroscopic unit and a signal processing unit.

Abstract translation: 本发明公开了一种通过拉曼系统测量受试者的皮肤厚度和血糖浓度的非侵入性方法。 本发明的优点是使用单个拉曼光谱来测量皮肤厚度和葡萄糖浓度。 从相同的拉曼光谱获取的皮肤厚度和拉曼强度都被用来产生更准确的血糖浓度。 本发明还公开了一种用于测量对象的生理数据的拉曼系统。 它包括拉曼光谱单元和信号处理单元。

公开(公告)号：US20140293279A1

公开(公告)日：2014-10-02

申请号：US13854975

申请日：2013-04-02

Applicant: Hong Kong Applied Science and Technology Research Institute Co. Ltd.

Inventor： Ka Cheung KWOK ,  Lut Hey CHU ,  Chun ZHANG ,  Lap Wai Lydia LEUNG

IPC: G01N21/65

CPC classification number: G01N21/65

Abstract: A Raman signal detection and analyzing system and a method thereof are disclosed. The Raman signal is generated by emitting an excitation light to a sample. The Raman signal is then modulated by passing through a plurality of optical filter and modulator. The resulting modulated Raman signal comprises two orthogonal components, which intensities are to be computed based on the first harmonic of said modulated Raman signal. The content of a specific analyte within the sample can then be determined based on the ratio of the intensities of the two components.

Abstract translation: 公开了一种拉曼信号检测和分析系统及其方法。 通过向样品发射激发光来产生拉曼信号。 然后通过穿过多个滤光器和调制器来调制拉曼信号。 所得到的调制拉曼信号包括两个正交分量，这些强度将基于所述调制拉曼信号的一次谐波计算。 然后可以基于两个组分的强度比来确定样品中特定分析物的含量。