公开(公告)号：US20140343032A1

公开(公告)日：2014-11-20

申请号：US14279716

申请日：2014-05-16

Applicant: Hoffmann-La Roche Inc.

Inventor： Lei Guo ,  Taishan Hu ,  Yimin Hu ,  Buelent Kocer ,  Buyu Kou ,  Gangqin Li ,  Xianfeng Lin ,  Haixia Liu ,  Hong Shen ,  Houguang Shi ,  Guolong Wu ,  Zhisen Zhang ,  Mingwei Zhou ,  Wei Zhu

IPC: C07D498/08 ,  C07D498/18 ,  C07D498/20 ,  C07D487/08 ,  C07D513/08 ,  C07D417/14 ,  C07D491/08

CPC classification number: C07D498/18 ,  A61K31/506 ,  C07D417/14 ,  C07D453/06 ,  C07D471/08 ,  C07D487/08 ,  C07D491/08 ,  C07D491/18 ,  C07D498/08 ,  C07D498/20 ,  C07D513/08

Abstract: The invention provides novel compounds having the general formula: wherein R1, R2, R3 and R4 are as defined in the description and in the claims, as well as or pharmaceutically acceptable salts, or tautomerism isomers, or enantiomers, or diastereomers thereof. The invention also contains compositions including the compounds and methods of using the compounds.

Abstract translation: 本发明提供具有以下通式的新化合物：其中R 1，R 2，R 3和R 4如说明书和权利要求书中所定义，以及其药学上可接受的盐或互变异构体异构体或其对映异构体或非对映异构体。 本发明还包含包含化合物的组合物和使用该化合物的方法。

公开(公告)号：US20200181156A1

公开(公告)日：2020-06-11

申请号：US16790400

申请日：2020-02-13

Applicant: Hoffmann-La Roche Inc.

Inventor： Taishan Hu ,  Buyu Kou ,  Haixia Liu ,  Zhisen Zhang ,  Zheng Zhou

IPC: C07D487/04 ,  C07D498/08 ,  C07D487/08 ,  A61P31/20

Abstract: The present invention relates to compounds of the formula (I), or pharmaceutically acceptable salts, enantiomer or diastereomer thereof, wherein R1 to R3 are as described above. The compounds may be useful for the treatment or prophylaxis of hepatitis B virus infection.

公开(公告)号：US10081627B2

公开(公告)日：2018-09-25

申请号：US14946595

申请日：2015-11-19

Applicant: Hoffmann-La Roche Inc.

Inventor： Lei Guo ,  Taishan Hu ,  Buyu Kou ,  Xianfeng Lin ,  Hong Shen ,  Houguang Shi ,  Shixiang Yan ,  Weixing Zhang ,  Zhisen Zhang ,  Mingwei Zhou ,  Wei Zhu

IPC: A61K31/519 ,  C07D471/04 ,  A61K31/4985 ,  C07D487/04 ,  C07D498/04 ,  C07D513/04 ,  A61K31/517

CPC classification number: C07D471/04 ,  A61K31/4985 ,  A61K31/517 ,  A61K31/519 ,  C07D487/04 ,  C07D498/04 ,  C07D513/04

Abstract: The invention provides novel compounds having the general formula: wherein R1, R2, R3, R4, R5, R6, X, Y, W and n are as described herein, compositions including the compounds and methods of using the compounds.

公开(公告)号：US20200062753A1

公开(公告)日：2020-02-27

申请号：US16531624

申请日：2019-08-05

Applicant: Hoffmann-La Roche Inc.

Inventor： Lei Guo ,  Taishan Hu ,  Buyu Kou ,  Xianfeng Lin ,  Hong Shen ,  Houguang Shi ,  Shixiang Yan ,  Weixing Zhang ,  Zhisen Zhang ,  Mingwei Zhou ,  Wei Zhu

IPC: C07D471/04 ,  A61K31/4985 ,  C07D487/04 ,  C07D513/04 ,  C07D498/04

Abstract: The invention provides novel compounds having the general formula: wherein R1, R2, R3, R4, R5, R6, X, Y, W and n are as described herein, compositions including the compounds and methods of using the compounds.

公开(公告)号：US20190322670A1

公开(公告)日：2019-10-24

申请号：US16247084

申请日：2019-01-14

Applicant: Hoffmann-La Roche Inc.

Inventor： Taishan Hu ,  Buyu Kou ,  Haixia Liu ,  Zhisen Zhang ,  Zheng Zhou

IPC: C07D487/04 ,  A61P31/20 ,  C07D498/08

Abstract: The present invention relates to compounds of the formula (I), or pharmaceutically acceptable salts, enantiomer or diastereomer thereof, wherein R1 to R3 are as described above. The compounds may be useful for the treatment or prophylaxis of hepatitis B virus infection.

公开(公告)号：US10428069B2

公开(公告)日：2019-10-01

申请号：US16103198

申请日：2018-08-14

Applicant: Hoffmann-La Roche Inc.

Inventor： Lei Guo ,  Taishan Hu ,  Buyu Kou ,  Xianfeng Lin ,  Hong Shen ,  Houguang Shi ,  Shixiang Yan ,  Weixing Zhang ,  Zhisen Zhang ,  Mingwei Zhou ,  Wei Zhu

IPC: C07D471/04 ,  A61K31/4985 ,  C07D487/04 ,  C07D498/04 ,  C07D513/04 ,  A61K31/517 ,  A61K31/519

Abstract: The invention provides novel compounds having the general formula: wherein R1, R2, R3, R4, R5, R6, X, Y, W and n are as described herein, compositions including the compounds and methods of using the compounds.

公开(公告)号：US20160083383A1

公开(公告)日：2016-03-24

申请号：US14946595

申请日：2015-11-19

Applicant: Hoffmann-La Roche Inc.

Inventor： Lei Guo ,  Taishan Hu ,  Buyu Kou ,  Xianfeng Lin ,  Hong Shen ,  Houguang Shi ,  Shixiang Yan ,  Weixing Zhang ,  Zhisen Zhang ,  Mingwei Zhou ,  Wei Zhu

IPC: C07D471/04 ,  C07D487/04 ,  C07D513/04 ,  C07D498/04

CPC classification number: C07D471/04 ,  A61K31/4985 ,  A61K31/517 ,  A61K31/519 ,  C07D487/04 ,  C07D498/04 ,  C07D513/04

Abstract: The invention provides novel compounds having the general formula: wherein R1, R2, R3, R4, R5, R6, X, Y, W and n are as described herein, compositions including the compounds and methods of using the compounds.

公开(公告)号：US09266904B2

公开(公告)日：2016-02-23

申请号：US14279716

申请日：2014-05-16

Applicant: Hoffmann-La Roche Inc.

Inventor： Lei Guo ,  Taishan Hu ,  Yimin Hu ,  Buelent Kocer ,  Buyu Kou ,  Gangqin Li ,  Xianfeng Lin ,  Haixia Liu ,  Hong Shen ,  Houguang Shi ,  Guolong Wu ,  Zhisen Zhang ,  Mingwei Zhou ,  Wei Zhu

IPC: A61K31/506 ,  C07D498/08 ,  C07D417/14 ,  C07D498/18 ,  C07D491/08 ,  C07D487/08 ,  C07D513/08 ,  C07D498/20 ,  C07D453/06 ,  C07D471/08 ,  C07D491/18

CPC classification number: C07D498/18 ,  A61K31/506 ,  C07D417/14 ,  C07D453/06 ,  C07D471/08 ,  C07D487/08 ,  C07D491/08 ,  C07D491/18 ,  C07D498/08 ,  C07D498/20 ,  C07D513/08

Abstract: The invention provides novel compounds having the general formula: wherein R1, R2, R3 and R4 are as defined in the description and in the claims, as well as or pharmaceutically acceptable salts, or tautomerism isomers, or enantiomers, or diastereomers thereof. The invention also contains compositions including the compounds and methods of using the compounds.

Abstract translation: 本发明提供具有以下通式的新化合物：其中R 1，R 2，R 3和R 4如说明书和权利要求书中所定义，以及其药学上可接受的盐或互变异构体异构体或其对映异构体或非对映异构体。 本发明还包含包含化合物的组合物和使用该化合物的方法。

公开(公告)号：US20240360126A1

公开(公告)日：2024-10-31

申请号：US18606123

申请日：2024-03-15

Applicant: Hoffmann-La Roche Inc.

Inventor： Dongdong Chen ,  Fabian Dey ,  Xin Hong ,  Xiaoqing Wang ,  Zhisen Zhang ,  Wei Zhu ,  Ge Zou

IPC: C07D471/04 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/497 ,  A61K31/506 ,  A61K31/5386 ,  A61K31/553 ,  C07D519/00

CPC classification number: C07D471/04 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/497 ,  A61K31/506 ,  A61K31/5386 ,  A61K31/553 ,  C07D519/00

Abstract: The present invention relates to compounds of formula (I),






wherein R1 to R3, A, M, W and Q are as described herein, and their pharmaceutically acceptable salt thereof, and compositions including the compounds and methods of using the compounds.

公开(公告)号：US10562905B2

公开(公告)日：2020-02-18

申请号：US16247084

申请日：2019-01-14

Applicant: Hoffmann-La Roche Inc.

Inventor： Taishan Hu ,  Buyu Kou ,  Haixia Liu ,  Zhisen Zhang ,  Zheng Zhou

IPC: C07D487/04 ,  C07D487/08 ,  C07D498/08 ,  A61P31/20

Abstract: The present invention relates to compounds of the formula (I), or pharmaceutically acceptable salts, enantiomer or diastereomer thereof, wherein R1 to R3 are as described above. The compounds may be useful for the treatment or prophylaxis of hepatitis B virus infection.