公开(公告)号：US20220267349A1

公开(公告)日：2022-08-25

申请号：US17588816

申请日：2022-01-31

Applicant: Hoffmann-La Roche Inc.

Inventor： Joerg BENZ ,  Luca GOBBI ,  Uwe GRETHER ,  Steven Paul HANLON ,  Benoit HORNSPERGER ,  Carsten KROLL ,  Bernd KUHN ,  Martin KURATLI ,  Guofu LIU ,  Fionn O`HARA ,  Hans RICHTER ,  Martin RITTER

IPC: C07D498/04

Abstract: The invention provides new heterocyclic compounds having the general formula (I) wherein A, L, Q, U, V, W, X, Z, m, n, and R1 to R4 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.

公开(公告)号：US20220220373A1

公开(公告)日：2022-07-14

申请号：US17700987

申请日：2022-03-22

Applicant: Hoffmann-La Roche Inc.

Inventor： Joerg BENZ ,  Thais GAZZI ,  Luca GOBBI ,  Uwe GRETHER ,  Benoit HORNSPERGER ,  Carsten KROLL ,  Bernd KUHN ,  Yelena MOSTINSKI ,  Marc NAZARE ,  Fionn O'HARA ,  Hans RICHTER

IPC: C09K11/06 ,  A61K49/00 ,  G01N33/58 ,  C07D498/04 ,  C07F5/02 ,  C09B57/00

Abstract: The invention provides fluorescent probes having the general formula (I) wherein X, Y, L and R1 to R4 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.

公开(公告)号：US20240150373A1

公开(公告)日：2024-05-09

申请号：US18475065

申请日：2023-09-26

Applicant: Hoffmann-La Roche Inc.

Inventor： Charles BELL ,  Joerg BENZ ,  Luca GOBBI ,  Uwe GRETHER ,  Katrin GROEBKE ZBINDEN ,  Benoit HORNSPERGER ,  Buelent KOCER ,  Carsten KROLL ,  Bernd KUHN ,  Marius Daniel Rinaldo LUTZ ,  Fionn O'HARA ,  Hans RICHTER ,  Martin RITTER ,  Didier ROMBACH ,  Martin KURATLI

IPC: C07D498/04 ,  C07D519/00

CPC classification number: C07D498/04 ,  C07D519/00

Abstract: The invention provides new heterocyclic compounds having the general formula (I)




wherein A, L, X, m, n, R1 and R2 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.

公开(公告)号：US20230050901A1

公开(公告)日：2023-02-16

申请号：US17749496

申请日：2022-05-20

Applicant: Hoffmann-La Roche Inc.

Inventor： Charles BELL ,  Joerg BENZ ,  Luca GOBBI ,  Uwe GRETHER ,  Katrin GROEBKE ZBINDEN ,  Benoit HORNSPERGER ,  Buelent KOCER ,  Carsten KROLL ,  Bernd KUHN ,  Marius Daniel Rinaldo LUTZ ,  Fionn O'HARA ,  Hans RICHTER ,  Martin RITTER ,  Didier ROMBACH ,  Martin KURATLI

IPC: C07D498/04 ,  C07D519/00

Abstract: The invention provides new heterocyclic compounds having the general formula (I) wherein A, L, X, m, n, R1 and R2 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.

公开(公告)号：US20220135591A1

公开(公告)日：2022-05-05

申请号：US17497633

申请日：2021-10-08

Applicant: Hoffmann-La Roche Inc.

Inventor： Joerg BENZ ,  Guillaume DECORET ,  Uwe GRETHER ,  Katrin GROEBKE ZBINDEN ,  Benoit HORNSPERGER ,  Bernd KUHN ,  Hans RICHTER ,  Didier ROMBACH ,  Fionn O'HARA ,  Carsten KROLL

IPC: C07D498/04 ,  C07D519/00

Abstract: The invention provides new heterocyclic compounds having the general formula (I) wherein R1 to R7, A, L1, and RA1 to RA3 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.

公开(公告)号：US20200308190A1

公开(公告)日：2020-10-01

申请号：US16844262

申请日：2020-04-09

Applicant: Hoffmann-La Roche Inc.

Inventor： Charles BELL ,  Joerg BENZ ,  Luca GOBBI ,  Uwe GRETHER ,  Katrin GROEBKE ZBINDEN ,  Benoit HORNSPERGER ,  Buelent KOCER ,  Carsten KROLL ,  Bernd KUHN ,  Marius Daniel Rinaldo LUTZ ,  Fionn O'HARA ,  Hans RICHTER ,  Martin RITTER ,  Didier ROMBACH ,  Martin KURATLI

IPC: C07D498/04 ,  C07D519/00

Abstract: The invention provides new heterocyclic compounds having the general formula wherein A, L, X, m, n, R1 and R2 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.

公开(公告)号：US20230203056A1

公开(公告)日：2023-06-29

申请号：US18172506

申请日：2023-02-22

Applicant: Hoffmann-La Roche Inc.

Inventor： Joerg BENZ ,  Uwe GRETHER ,  Benoit HORNSPERGER ,  Carsten KROLL ,  Bernd KUHN ,  Rainer E. MARTIN ,  Fionn O'HARA ,  Hans RICHTER ,  Martin RITTER ,  Philipp SCHMID

IPC: C07D491/147 ,  C07D487/04

CPC classification number: C07D491/147 ,  C07D487/04

Abstract: The invention provides new heterocyclic compounds having the general formula (I)




wherein X, Y, Z, A, L, B, and R1 to R3 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.

公开(公告)号：US20230117324A1

公开(公告)日：2023-04-20

申请号：US17818459

申请日：2022-08-09

Applicant: Hoffmann-La Roche Inc.

Inventor： Charles BELL ,  Joerg BENZ ,  Luca GOBBI ,  Uwe GRETHER ,  Katrin GROEBKE ZBINDEN ,  Dennis Jul HANSEN ,  Benoit HORNSPERGER ,  Buelent KOCER ,  Carsten KROLL ,  Bernd KUHN ,  Fionn O'HARA ,  Hans RICHTER ,  Martin RITTER ,  Satoshi TSUCHIYA ,  Rui CHEN

IPC: C07D498/04 ,  A61K9/20 ,  A61K9/48 ,  C07D519/00

Abstract: The invention provides new heterocyclic compounds having the general formula (Ic) wherein A, L, X, m, n and R20 to R23 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.

公开(公告)号：US20220098176A1

公开(公告)日：2022-03-31

申请号：US17465536

申请日：2021-09-02

Applicant: Hoffmann-La Roche Inc.

Inventor： Joerg BENZ ,  Uwe GRETHER ,  Benoit HORNSPERGER ,  Carsten KROLL ,  Bernd KUHN ,  Rainer E. MARTIN ,  Fionn O'HARA ,  Bernd PUELLMANN ,  Hans RICHTER ,  Martin RITTER

IPC: C07D403/06 ,  C07D487/04 ,  C07D401/14 ,  C07D413/06 ,  C07D413/14 ,  A61K9/20 ,  A61K9/48

Abstract: The invention provides new heterocyclic compounds having the general formula (I) wherein B, C, L, X, Y, RL and R3 to R5 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.

公开(公告)号：US20210107920A1

公开(公告)日：2021-04-15

申请号：US17025155

申请日：2020-09-18

Applicant: Hoffmann-La Roche Inc.

Inventor： Charles BELL ,  Joerg BENZ ,  Luca GOBBI ,  Uwe GRETHER ,  Katrin GROEBKE ZBINDEN ,  Dennis Jul HANSEN ,  Benoit HORNSPERGER ,  Buelent KOCER ,  Carsten KROLL ,  Bernd KUHN ,  Fionn O'HARA ,  Hans RICHTER ,  Martin RITTER ,  Satoshi TSUCHIYA ,  Rui CHEN

IPC: C07D498/04 ,  C07D519/00 ,  A61K9/20 ,  A61K9/48

Abstract: The invention provides new heterocyclic compounds having the general formula (Ic) wherein A, L, X, m, n and R20 to R23 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.