公开(公告)号：US07556926B2

公开(公告)日：2009-07-07

申请号：US10515720

申请日：2003-05-22

申请人： Hideaki Tojo ,  Tsutomu Henta ,  Reiko Sasada

发明人： Hideaki Tojo ,  Tsutomu Henta ,  Reiko Sasada

IPC分类号： G01N33/55 ,  G01N33/554 ,  A61K38/24

CPC分类号： C07K14/47 ,  A61K31/7088

摘要： A compound or its salt inhibiting the activity of a protein having an amino acid sequence which is the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1, an extracellular domain of the protein above, an antibody, an antisense polynucleotide, etc. are usable as insulin-sensitizing agents and preventives and/or remedies for diabetes, obesity, hyperlipemia, arteriosclerosis, hypertension, heart disease, and so on.

摘要翻译： 抑制具有与SEQ ID NO：1表示的氨基酸序列相同或基本相同的氨基酸序列的蛋白质的活性的化合物或其盐，上述蛋白质的细胞外结构域，抗体 ，反义多核苷酸等可用作糖尿病，肥胖症，高脂血症，动脉硬化，高血压，心脏病等的胰岛素敏化剂和预防剂和/或治疗药物。

公开(公告)号：US20060014679A1

公开(公告)日：2006-01-19

申请号：US10515720

申请日：2003-05-22

申请人： Hideaki Tojo ,  Tsutomu Henta ,  Reiko Sasada

发明人： Hideaki Tojo ,  Tsutomu Henta ,  Reiko Sasada

IPC分类号： A61K48/00 ,  A61K38/22 ,  C07H21/02 ,  C07K14/575

CPC分类号： C07K14/47 ,  A61K31/7088

摘要： A compound or its salt inhibiting the activity of a protein having an amino acid sequence which is the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1, an extracellular domain of the protein above, an antibody, an antisense polynucleotide, etc. are usable as insulin-sensitizing agents and preventives and/or remedies for diabetes, obesity, hyperlipemia, arteriosclerosis, hypertension, heart disease, and so on.

摘要翻译： 抑制具有与SEQ ID NO：1表示的氨基酸序列相同或基本相同的氨基酸序列的蛋白质的活性的化合物或其盐，上述蛋白质的细胞外结构域，抗体 ，反义多核苷酸等可用作糖尿病，肥胖症，高脂血症，动脉硬化，高血压，心脏病等的胰岛素敏化剂和预防剂和/或治疗药物。