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1.发明申请Composition Comprising Colony Stimulating Factor for Treatment of a Localised Bacterial Infection and Bacterial Related Disease 有权包含用于治疗局部细菌感染和细菌相关疾病的集落刺激因子的组合物公开(公告)号：US20080038222A1
公开(公告)日：2008-02-14
申请号：US10599753
申请日：2005-04-08
申请人： Henrik Arnberg
发明人： Henrik Arnberg
CPC分类号： A61K38/193 , A61K9/0063 , A61K38/00
摘要： The invention provides a composition for treatment of a localized bacterial infection comprising at least one CSF or fragment or derivative thereof. Also provided is the use of at least one colony stimulating factor (CSF) or fragment or derivative thereof having essentially the biological functionality and activity of the CSF for preparing a medicament for the treatment of a localized bacterial infection. The CSF is selected from granulocyte colony-stimulating factor, macrophage colony-stimulating factor, granulocyte-macrophage colony-stimulating factor and multi-colony stimulating factor. A method of treatment of a mammal suffering from a localized bacterial infection is provided. The localized bacterial infection may be a periodontal disease or sinusitis.
摘要翻译： 本发明提供用于治疗局部细菌感染的组合物，其包含至少一种CSF或其片段或衍生物。 还提供了至少一种具有基本上具有CSF的生物功能和活性的集落刺激因子（CSF）或其片段或衍生物用于制备用于治疗局部细菌感染的药物的用途。 CSF选自粒细胞集落刺激因子，巨噬细胞集落刺激因子，粒细胞 - 巨噬细胞集落刺激因子和多集落刺激因子。 提供了治疗局部细菌感染的哺乳动物的方法。 局部细菌感染可能是牙周病或鼻窦炎。
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2.发明授权Method of treating periodontal diseases by administering a therapeutically effective amount of GM-CSF 有权通过施用治疗有效量的GM-CSF治疗牙周病的方法公开(公告)号：US07888312B2
公开(公告)日：2011-02-15
申请号：US10599753
申请日：2005-04-08
申请人： Henrik Arnberg
发明人： Henrik Arnberg
IPC分类号： A61K38/00
CPC分类号： A61K38/193 , A61K9/0063 , A61K38/00
摘要： The invention provides a composition for treatment of a localized bacterial infection and bacterial related disease comprising at least one CSF or fragment or derivative thereof. Also provided is the use of at least one colony stimulating factor (CSF) or fragment or derivative thereof having essentially the biological functionality and activity of the CSF for preparing a medicament for the treatment of a localized bacterial infection and bacterial related disease. The CSF is selected from granulocyte colony-stimulating factor (G-CSF), macrophage colony-stimulating factor (M-CSF), granulocyte-macrophage colony-stimulating factor (GM-CSF), and multi-colony stimulating factor. A method of treatment of a mammal suffering from a localized bacterial infection and bacterial related disease is provided. The localized bacterial infection and bacterial related disease may be a periodontal disease or sinusitis.
摘要翻译： 本发明提供用于治疗局部细菌感染和细菌相关疾病的组合物，其包含至少一种CSF或其片段或衍生物。 还提供了至少一种具有基本上具有CSF的生物功能和活性的集落刺激因子（CSF）或其片段或衍生物用于制备用于治疗局部细菌感染和细菌相关疾病的药物的用途。 CSF选自粒细胞集落刺激因子（G-CSF），巨噬细胞集落刺激因子（M-CSF），粒细胞 - 巨噬细胞集落刺激因子（GM-CSF）和多集落刺激因子。 提供了治疗局部细菌感染和细菌相关疾病的哺乳动物的治疗方法。 局部细菌感染和细菌相关疾病可能是牙周病或鼻窦炎。
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