公开(公告)号：US20220088031A1

公开(公告)日：2022-03-24

申请号：US17423959

申请日：2020-01-31

申请人： Health Research, Inc.

发明人： Dhyan Chandra ,  Rahul Kumar ,  Neelu Yadav

IPC分类号： A61K31/555 ,  A61K31/337 ,  A61K31/136 ,  A61K31/565 ,  A61K31/19 ,  A61P35/00 ,  A61K31/426

摘要： A method for treating prostate cancer in a subject involves selecting a subject having prostate cancer and cytochrome c-deficiency, and administering, to the selected subject, a therapeutically effective amount of one or more agents capable of restoring cytochrome-c activity. Also presented is a method of inducing apoptosis in drug resistant cancer cells involving selecting drug resistant cancer cells having cytochrome-c deficiency, and administering to the selected cells, one or more agents that restore cytochrome-c activity in an amount effective to sensitize said cancer cells to drug induced apoptosis. A combination therapeutic comprising one or more agents increases cytochrome-c activity and efficacy of a chemotherapeutic agent. Another method involves selecting a subject having cancer, and obtaining a cell sample including tumor tissues/biopsy and blood samples from said subject, and further involves measuring cytochrome-c expression levels and Drp1 phosphorylation levels in said sample.