公开(公告)号：US20120219960A1

公开(公告)日：2012-08-30

申请号：US13338794

申请日：2011-12-28

申请人： Hagan BAYLEY ,  Yann ASTIER ,  Orit BRAHA

发明人： Hagan BAYLEY ,  Yann ASTIER ,  Orit BRAHA

IPC分类号： G01N27/26

CPC分类号： G01N33/48721 ,  C12Q1/6869 ,  C12Q2565/631

摘要： The invention relates to a method of identifying an individual nucleotide, comprising (a) contacting the nucleotide with a transmembrane protein pore so that the nucleotide interacts with the pore and (b) measuring the current passing through the pore during the interaction and thereby determining the identity of the nucleotide. The invention also relates to a method of sequencing nucleic acid sequences and kits related thereto.

摘要翻译： 本发明涉及鉴定个体核苷酸的方法，其包括（a）使核苷酸与跨膜蛋白质孔接触，使得核苷酸与孔相互作用，和（b）在相互作用期间测量通过孔的电流，从而确定 核苷酸的同一性。 本发明还涉及对与其相关的核酸序列和试剂盒进行测序的方法。