公开(公告)号：US20180113119A1

公开(公告)日：2018-04-26

申请号：US15559452

申请日：2016-03-21

Applicant: HUREL CORPORATION

Inventor： Robert FREEDMAN ,  James MACDONALD ,  Eric NOVIK

IPC: G01N33/50

CPC classification number: G01N33/5067 ,  G01N33/5014 ,  G01N33/5044 ,  G01N2333/90258

Abstract: Methods of characterizing the time-based hepatotoxicity of a test compound are provided. In some embodiments the provided methods allow prediction of the hepatotoxic potential of a test compound in a way that is improved relative to that achievable with prior art methods. In some embodiments the methods may be used to quantify the relationship between measurements or estimates of toxicity made at different, successive points in time, to provide highly meaningful tool to assess the likely in vivo hepatotoxicity of test compounds in vivo.