公开(公告)号：US3684791A

公开(公告)日：1972-08-15

申请号：US3684791D

申请日：1969-09-22

Applicant: HOECHST AG

Inventor： GEIGER ROLF ,  PFAFF WERNER ,  BANDER ALFRED ,  SCHONE HANS-HERMANN ,  MAGER ADOLF

IPC: A61K38/00 ,  C07K14/62 ,  A61K17/02 ,  C07C103/52

CPC classification number: C07K14/62 ,  A61K38/00

Abstract: N (A1), N (B29)-di-tert. butyloxycarbonyl insulin, useful as a hypoglycemic agent. A method for its preparation by reacting insulin, in a mixture of an N,N''-dialkylcarboxylic acid amide having a total of from three to six carbon atoms and an aqueous buffer solution having a pH between 8.0 and 9.0, with a 20 to 75 fold molar excess of tert. butyloxycarbonyl azide at 20* to 50*C.

Abstract translation: N（A1），N（B29） - 二叔丁基。 丁氧羰基胰岛素，可用作降血糖药。 其制备方法是使胰岛素在总共3至6个碳原子的N，N'-二烷基羧酸酰胺与pH为8.0-9.0的水溶液的混合物中反应20至75 倍摩尔过量的叔。 丁氧基羰基叠氮化物在20〜50℃