公开(公告)号：US11033511B2

公开(公告)日：2021-06-15

申请号：US16610955

申请日：2018-07-30

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Akira Shuto ,  Takao Kurokawa ,  Junya Horiuchi ,  Hidekazu Kuma ,  Satoshi Amano

IPC: A61K9/70 ,  A61K31/216

Abstract: The present invention provides a patch comprising a backing, and an adhesive layer on the backing, wherein the adhesive layer contains at least one drug selected from the group consisting of oxybutynin and a pharmaceutically acceptable salt thereof, a pressure-sensitive adhesive base, and diflucortolone valerate, and the content of the diflucortolone valerate is 0.0007 to 0.05% by mass based on the total mass of the adhesive layer.

公开(公告)号：US11607394B2

公开(公告)日：2023-03-21

申请号：US16954627

申请日：2018-12-14

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Hiroyuki Araki ,  Yuka Takagi ,  Yoko Fujiwara ,  Hiroaki Kobayashi ,  Takao Kurokawa

IPC: A61P25/16 ,  A61K47/32 ,  A61K31/381 ,  A61K9/70

Abstract: The present invention provides a rotigotine-containing patch comprising: a backing layer; and an adhesive agent layer, wherein the adhesive agent layer contains rotigotine and/or a pharmaceutically acceptable salt thereof,
the adhesive agent layer further contains a styrene-based thermoplastic elastomer, a petroleum-based resin and/or a terpene-based resin, an aliphatic alcohol, and a cross-linked polyvinylpyrrolidone, and
in the adhesive agent layer, a mass ratio of a content of the rotigotine and/or the pharmaceutically acceptable salt thereof in terms of rotigotine free form and a content of the cross-linked polyvinylpyrrolidone (content of the rotigotine and/or the pharmaceutically acceptable salt thereof in terms of rotigotine free form:content of the cross-linked polyvinylpyrrolidone) is 10:3 to 1:3.

公开(公告)号：US12151030B2

公开(公告)日：2024-11-26

申请号：US17426796

申请日：2020-01-30

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Takao Kurokawa ,  Hidekazu Kuma ,  Masaki Yukuhiro

IPC: A61K9/70 ,  A61K31/13 ,  A61K31/27 ,  A61K31/381 ,  A61K31/403 ,  A61K31/407 ,  A61K31/4422 ,  A61K31/573

Abstract: The present invention provides a patch comprising an adhesive layer on a backing, wherein the adhesive layer contains a adhesive base, a skin irritant drug or a pharmaceutically acceptable salt thereof, and diflucortolone valerate, and the content of the diflucortolone valerate is 0.0009 to 0.08% by mass based on the total mass of the adhesive layer.