公开(公告)号：US09115118B2

公开(公告)日：2015-08-25

申请号：US14264450

申请日：2014-04-29

申请人： HETERO RESEARCH FOUNDATION

发明人： Bandi Parthasaradhi Reddy ,  Kura Rathnakar Reddy ,  Rapolu Raji Reddy ,  Dasari Muralidhara Reddy ,  Bandi Vamsi Krishna ,  Voggu Ramesh Reddy

IPC分类号： C07D401/14 ,  C07D401/12

CPC分类号： C07D401/12 ,  C07D401/14

摘要： The present invention relates to process for the resolution of omeprazole. The present invention further provides a novel compound of enantiomers of omeprazole cyclic amine salt and a process for preparing it. The present invention also provides a solid of (R)- or (S)-omeprazole cyclic amine salt and a process for preparing it. The present invention also provides a process for the preparation of esomeprazole magnesium dehydrate substantially free of its trihydrate form. The present invention also provides a process for the preparation of recovery of chiral BINOL.

摘要翻译： 本发明涉及奥美拉唑的分辨方法。 本发明还提供了奥美拉唑环胺盐的新型对映体化合物及其制备方法。 本发明还提供（R） - 或（S） - 奥美拉唑环胺盐的固体及其制备方法。 本发明还提供一种制备基本上不含其三水合物形式的艾司替唑无水脱水制剂的方法。 本发明还提供了制备手性BINOL回收的方法。