公开(公告)号：US20230312493A1

公开(公告)日：2023-10-05

申请号：US18004099

申请日：2021-07-09

Applicant: HELMHOLTZ-ZENTRUM DRESDEN-ROSSENDORF E.V.

Inventor： Rares-Petru MOLDOVAN ,  Rodrigo TEODORO ,  Magali TOUSSAINT ,  Daniel GÜNDEL ,  Winnie DEUTHER-CONRAD ,  Peter BRUST

IPC: C07D277/18 ,  A61K51/04

CPC classification number: C07D277/18 ,  A61K51/0453

Abstract: Compounds of general formula I





X1 is a CD2 group or a CT2 group; X2 is oxygen or a group (CZ1Z2)n, wherein Z1 and Z2 on each occurrence independently each are hydrogen, deuterium, or tritium and n is an integer from 1 to 12; X3 is a CD2 group or a CT2 group; and R is selected from the group consisting of hydroxy, -NO2, halogen, a diazonium ion, a diazonium salt, a trialkylammonium ion, a trialkylammonium salt, a dialkoxyarene, a sulphoxide, a boronic acid, a boronic acid ester, an organotin compound, an iodonium ion, an iodonium salt, an iodonium ylide, and a sulphonate.

公开(公告)号：US20230095104A1

公开(公告)日：2023-03-30

申请号：US17620848

申请日：2020-06-22

Applicant: HELMHOLTZ-ZENTRUM DRESDEN-ROSSENDORF E.V. ,  ROTOP PHARMAKA GMBH

Inventor： Thu Hang LAI ,  Rodrigo TEODORO ,  Magali TOUSSAINT ,  Daniel GÜNDEL ,  Winnie DEUTHER-CONRAD ,  Sladjana DUKIC-STEFANOVIC ,  Susann SCHRÖDER ,  Rares-Petru MOLDOVAN ,  Peter BRUST

IPC: C07D487/14

Abstract: A compound of general formula I Residues X1a, X1b, X2a, X2b, X3a, X3b, X4a, X4b, X5a, and X5b each independently are hydrogen or deuterium, with the provision that at least one of residues X1a, X1b, X2a, X2b, X3a, X3b, X4a, X4b, X5a, and X5b is deuterium.