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公开(公告)号：US20230118307A1
公开(公告)日：2023-04-20
申请号：US17792228
申请日：2020-11-20
发明人： Seon Myeong LEE , Jong Suk LEE , Jung Kuk KIM , Sang Hyun LEE , Euh Lim OH , Hyo Sang JO , Eun Jin PARK , Chong Yoon LIM
摘要： New uses of a triple agonist are disclosed. A triple agonist having activities to all of glucagon, GLP-1, and GIP receptors, or conjugates thereof exhibits an activity of preventing and/or treating lung diseases. A use of the triple agonist or a conjugate thereof as a preventive and/or therapeutic agent for lung disease, and compositions and methods for preventing and/or treating lung cancer employing the triple agonist having activities to all of glucagon, GLP-1, and GIP receptors, and/or conjugates are disclosed.
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2.发明公开公开(公告)号：US20240197834A1
公开(公告)日：2024-06-20
申请号：US18285753
申请日：2022-04-11
发明人： Seon Myeong LEE , Jong Suk LEE , Jung Kuk KIM , Eun Jin PARK
CPC分类号： A61K38/26 , A61K47/6835 , A61P13/12
摘要： Provided are a glucagon derivative and use thereof. The pharmaceutical composition contains a glucagon derivative and a pharmaceutically acceptable excipient, wherein the glucagon derivative is a peptide including an amino acid sequence of the following General Formula 1: X1-X2-QGTF-X7-SD-X10-S-X12-X13-X14-X15-X16-X17-X18-X19-X20-X21-F-X23-X24-W-L-X27-X28-X29-X30 (General Formula 1, SEQ ID NO: 46). A method for treating chronic renal disease is also disclosed.
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公开(公告)号：US20230159607A1
公开(公告)日：2023-05-25
申请号：US17915976
申请日：2021-04-02
发明人： Jin Bong LEE , Jae Hyuk CHOI , Eun Jin PARK
IPC分类号： C07K14/605 , A61K47/60 , A61K45/06 , A61P1/04
CPC分类号： C07K14/605 , A61K47/60 , A61K45/06 , A61P1/04
摘要： A use of GLP-2 and a long-acting conjugate thereof for preventing or treating mucositis induced by radiotherapy, chemotherapy, or a combination thereof is disclosed. The GLP-2, the long-acting conjugate thereof, or the composition including the same may be applied to preparation, treatment, and amelioration of mucositis induced by radiotherapy and/or chemotherapy.
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