公开(公告)号：US20250032464A1

公开(公告)日：2025-01-30

申请号：US18707240

申请日：2022-11-01

Applicant: HAIHE BIOPHARMA CO., LTD.

Inventor： Yong GAN ,  Miao ZHU ,  Yuanhui MA ,  Lei LIU ,  Shiyan GUO ,  Jingkang SHEN ,  Meiyu GENG ,  Li GAO ,  Bing XIONG

IPC: A61K31/437 ,  A61K9/16 ,  A61K9/20 ,  A61K9/28 ,  A61K9/48

Abstract: A solid dispersion, a preparation method therefor, and a solid formulation comprising same. The solid dispersion comprises compound A and a pharmaceutically acceptable matrix polymer, wherein the pharmaceutically acceptable matrix polymer includes an enteric high-molecular polymer and a non-enteric high-molecular polymer, and the compound A is 1-{(6-[(1-methyl)-4-pyrazolyl]-imidazo[1,2-a]pyridine)-3-sulfonyl}-6-[(1-methyl)-4-pyrazolyl]-1-hydro-pyrazolo[4,3-b]pyridine. The solid dispersion can significantly improve the solubility and dissolution stability of the compound A, prolong the supersaturation maintenance time of a drug, and further improve the bioavailability of the drug. The in vivo bioavailability of a solid formulation prepared from the solid dispersion meets the requirement of oral administration of the compound A.