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公开(公告)号：US09393248B1
公开(公告)日：2016-07-19
申请号：US15071955
申请日：2016-03-16
发明人： Gitte Kobberøe Mikkelsen , Laurent David , Stephen Watson , Garrick Paul Smith , Douglas Stewart Williamson , I-Jen Chen
IPC分类号： A61K31/5377 , A61K31/4439 , A61K31/4545 , A61K31/497
CPC分类号： A61K31/5377 , A61K31/4439 , A61K31/4545 , A61K31/497 , C07D401/04 , C07D401/14 , C07D403/14 , C07D413/04 , C07D413/14
摘要： The present invention is directed to aminopyridine derived compounds of formula (A) The compounds are considered useful for the treatment of diseases associated with LRRK2 such as a Lewy body dementia, Parkinson's disease or cancer.
摘要翻译： 本发明涉及衍生自式（A）的氨基吡啶衍生化合物。该化合物被认为可用于治疗与LRRK2相关的疾病，例如路易体痴呆，帕金森病或癌症。
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公开(公告)号：US20140315901A1
公开(公告)日：2014-10-23
申请号：US14255317
申请日：2014-04-17
IPC分类号： C07D471/04
CPC分类号： A61K31/437 , A61K31/444 , A61K31/5377 , C07D471/04
摘要： The present invention is directed to arylpyrrolopyridine derivatives of formula (A) The compounds are considered useful for the treatment of diseases associated with LRRK2 such as Lewy body dementia, Parkinson's disease or cancer.
摘要翻译： 本发明涉及式（A）的芳基吡咯并吡啶衍生物。该化合物被认为可用于治疗与LRRK2相关的疾病如路易体痴呆，帕金森病或癌症。
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公开(公告)号：US20150336942A1
公开(公告)日：2015-11-26
申请号：US14758884
申请日：2013-12-30
发明人： Gitte Kobberøe Mikkelsen , Laurent David , Stephen Watson , Garrick Paul Smith , Douglas Stewart Williamson , I-Jen Chen
IPC分类号： C07D413/14 , C07D403/14
CPC分类号： A61K31/5377 , A61K31/4439 , A61K31/4545 , A61K31/497 , C07D401/04 , C07D401/14 , C07D403/14 , C07D413/04 , C07D413/14
摘要： The present invention is directed to aminopyridine derived compounds of formula (A). The compounds are considered useful for the treatment of diseases associated with LRRK2 such a Lewy body dementia, Parkinson's disease or cancer.
摘要翻译： 本发明涉及氨基吡啶衍生的式（A）化合物。 该化合物被认为可用于治疗与LRRK2相关的疾病如路易体痴呆，帕金森病或癌症。
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公开(公告)号：US09675594B2
公开(公告)日：2017-06-13
申请号：US15288255
申请日：2016-10-07
IPC分类号： C07D401/02 , C07D401/14 , A61K31/437 , A61K31/4353 , C07D471/04 , A61K31/444 , A61K31/5377
CPC分类号： A61K31/437 , A61K31/444 , A61K31/5377 , C07D471/04
摘要： The present invention is directed to arylpyrrolopyridine derivatives of Formula A: The compounds are considered useful for the treatment of diseases associated with LRRK2 such as Lewy body dementia, Parkinson's disease or cancer.
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公开(公告)号：US09499542B2
公开(公告)日：2016-11-22
申请号：US14777805
申请日：2014-04-14
IPC分类号： C07D401/02 , C07D401/14 , A61K31/437 , A61K31/4353 , C07D471/04
CPC分类号： A61K31/437 , A61K31/444 , A61K31/5377 , C07D471/04
摘要： The present invention is directed to arylpyrrolopyridine derivatives of formula (A) (A). The compounds are considered useful for the treatment of diseases associated with LRRK2 such as Lewy body dementia, Parkinson's disease cancer.
摘要翻译： 本发明涉及式（A）的芳基吡咯并吡啶衍生物。该化合物被认为可用于治疗与LRRK2相关的疾病如路易体痴呆，帕金森病或癌症。
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公开(公告)号：US20160184317A1
公开(公告)日：2016-06-30
申请号：US15071955
申请日：2016-03-16
发明人： Gitte Kobberøe Mikkelsen , Laurent David , Stephen Watson , Garrick Paul Smith , Douglas Stewart Williamson , I-Jen Chen
IPC分类号： A61K31/5377 , A61K31/4545 , A61K31/497 , A61K31/4439
CPC分类号： A61K31/5377 , A61K31/4439 , A61K31/4545 , A61K31/497 , C07D401/04 , C07D401/14 , C07D403/14 , C07D413/04 , C07D413/14
摘要： The present invention is directed to aminopyridine derived compounds of formula (A) The compounds are considered useful for the treatment of diseases associated with LRRK2 such a Lewy body dementia, Parkinson's disease or cancer.
摘要翻译： 本发明涉及衍生自式（A）的氨基吡啶衍生化合物。该化合物被认为可用于治疗与LRRK2相关的疾病如路易体痴呆，帕金森病或癌症。
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公开(公告)号：US09321748B2
公开(公告)日：2016-04-26
申请号：US14758884
申请日：2013-12-30
发明人： Gitte Kobberøe Mikkelsen , Laurent David , Stephen Watson , Garrick Paul Smith , Douglas Stewart Williamson , I-Jen Chen
IPC分类号： C07D401/04 , C07D401/14 , C07D403/14 , C07D413/04 , C07D413/14
CPC分类号： A61K31/5377 , A61K31/4439 , A61K31/4545 , A61K31/497 , C07D401/04 , C07D401/14 , C07D403/14 , C07D413/04 , C07D413/14
摘要： The present invention is directed to aminopyridine derived compounds of formula (A). The compounds are considered useful for the treatment of diseases associated with LRRK2 such a Lewy body dementia, Parkinson's disease or cancer.
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公开(公告)号：US20160102089A1
公开(公告)日：2016-04-14
申请号：US14777805
申请日：2014-04-14
IPC分类号： C07D471/04
CPC分类号： A61K31/437 , A61K31/444 , A61K31/5377 , C07D471/04
摘要： The present invention is directed to arylpyrrolopyridine derivatives of formula (A) (A). The compounds are considered useful for the treatment of diseases associated with LRRK2 such as Lewy body dementia, Parkinson's disease cancer.
摘要翻译： 本发明涉及式（A）（A）的芳基吡咯并吡啶衍生物。 该化合物被认为可用于治疗与LRRK2相关的疾病，例如路易体痴呆，帕金森氏病。
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公开(公告)号：US10689364B2
公开(公告)日：2020-06-23
申请号：US15704330
申请日：2017-09-14
发明人： James Edward Paul Davidson , James Brooke Murray , I-Jen Chen , Claire Walmsley , Mark Dodsworth , Johannes W. G. Meissner , Paul Brough , Imre Fejes , János Tatai , Miklós Nyerges , András Kotschy , Zoltán Szlávik , Olivier Geneste , Arnaud Le Tiran , Thierry Le Diguarher , Jean-Michel Henlin , Jérôme-Benoît Starck , Anne-Françoise Guillouzic , Guillaume De Nanteuil
IPC分类号： C07D401/14 , C07D405/14 , A61K31/4725 , C07D409/14 , C07D471/04 , A61K31/496 , A61K31/497 , A61K31/5377 , A61K31/675 , A61K45/06 , A61N5/10 , C07D417/14 , C07F9/6561
摘要： Compounds of formula (I): wherein Het, R3, R4, R5, R7, R8, R9, T, p, p′, q, and q′ are as defined in the description. Medicinal products containing the same which are useful in treating conditions requiring a pro-apoptotic agent.
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10.发明申请公开(公告)号：US20190248805A1
公开(公告)日：2019-08-15
申请号：US16394308
申请日：2019-04-25
发明人： Balázs Bálint , Márton Csékei , Zoltán Szabó , Zoltán Szlávik , András Kotschy , Maïa Chanrion , Olivier Geneste , I-Jen Chen , James Edward Paul Davidson , James Brooke Murray , Szabolcs Sipos , Levente Ondi , Ágnes Proszenyák
IPC分类号： C07D495/04 , C07D491/048 , C07D491/04 , C07D333/56 , A61P35/02 , C07D307/81 , C07D307/80 , C07D209/12 , C07D403/12 , C07D487/04 , C07D471/04 , C07D409/12 , C07D405/12 , C07D405/04
CPC分类号： C07D495/04 , A61K45/06 , A61K2300/00 , A61P35/02 , C07D209/12 , C07D307/80 , C07D307/81 , C07D333/56 , C07D403/12 , C07D405/04 , C07D405/12 , C07D409/12 , C07D471/04 , C07D487/04 , C07D491/04 , C07D491/048
摘要： Compounds of formula (I): wherein R1, R2, R3, R4, R5, R6, R7, R8, R14, W, A and n are as defined in the description.Medicinal products containing the same which are useful in treating conditions requiring a pro-apoptotic agent.
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