公开(公告)号：US20110104288A1

公开(公告)日：2011-05-05

申请号：US12917904

申请日：2010-11-02

申请人： Gregory Thoorens ,  Bruno LeClercq ,  Thomas Ruszkay

发明人： Gregory Thoorens ,  Bruno LeClercq ,  Thomas Ruszkay

IPC分类号： A61K9/14 ,  A61K47/02

CPC分类号： A61K9/2009 ,  A61K9/1611 ,  A61K9/1652 ,  A61K9/2054 ,  A61K31/375

摘要： Coprocessed compositions containing calcium phosphate and microcrystalline cellulose are useful as excipients in the preparation of solid dosage forms containing active pharmaceutical ingredients, particularly those prepared by processes involving multiple compaction steps. Such compositions may be obtained by preparing aqueous slurries of microcrystalline cellulose and calcium phosphate and drying such slurries to produce particulate products. The coprocessed products exhibit improved compactibility, as compared to dry physical blends of the same components.

摘要翻译： 包含磷酸钙和微晶纤维素的共加工组合物可用作制备含有活性药物成分的固体剂型的赋形剂，特别是通过涉及多次压实步骤的方法制备的那些。 这样的组合物可以通过制备微晶纤维素和磷酸钙的水性浆料并干燥这样的浆料以产生颗粒产物来获得。 与相同组分的干物理混合物相比，共加工产品表现出改进的紧密性。

公开(公告)号：US08632818B2

公开(公告)日：2014-01-21

申请号：US12917991

申请日：2010-11-02

申请人： Gregory Thoorens ,  Bruno LeClercq ,  Thomas Ruszkay

发明人： Gregory Thoorens ,  Bruno LeClercq ,  Thomas Ruszkay

IPC分类号： A61K9/16 ,  A61K9/20 ,  A61K47/38 ,  G01N3/08

CPC分类号： A61K31/375 ,  A61K9/2009 ,  A61K9/2054 ,  A61K47/02 ,  A61K47/38

摘要： Compositions containing calcium phosphate and microcrystalline cellulose are useful as excipients in the preparation of solid dosage forms containing active pharmaceutical ingredients, particularly those prepared by processes involving multiple compaction steps. The recompactibility performance of such compositions is improved through the use of calcium phosphate having a relatively small particle size, e.g., a median particle size of not more than about 20 microns or not more than about 10 microns.

摘要翻译： 含有磷酸钙和微晶纤维素的组合物可用作制备含有活性药物成分的固体剂型的赋形剂，特别是通过涉及多次压实步骤的方法制备的那些。 通过使用具有相对较小粒度的磷酸钙，例如不大于约20微米或不大于约10微米的中值粒度，可以改善这种组合物的可再现性能。

公开(公告)号：US08329221B2

公开(公告)日：2012-12-11

申请号：US12917904

申请日：2010-11-02

申请人： Gregory Thoorens ,  Bruno LeClercq ,  Thomas Ruszkay

发明人： Gregory Thoorens ,  Bruno LeClercq ,  Thomas Ruszkay

IPC分类号： A61K9/14 ,  A61K47/02

CPC分类号： A61K9/2009 ,  A61K9/1611 ,  A61K9/1652 ,  A61K9/2054 ,  A61K31/375

摘要： Coprocessed compositions containing calcium phosphate and microcrystalline cellulose are useful as excipients in the preparation of solid dosage forms containing active pharmaceutical ingredients, particularly those prepared by processes involving multiple compaction steps. Such compositions may be obtained by preparing aqueous slurries of microcrystalline cellulose and calcium phosphate and drying such slurries to produce particulate products. The coprocessed products exhibit improved compactibility, as compared to dry physical blends of the same components.

摘要翻译： 包含磷酸钙和微晶纤维素的共加工组合物可用作制备含有活性药物成分的固体剂型的赋形剂，特别是通过涉及多次压实步骤的方法制备的那些。 这样的组合物可以通过制备微晶纤维素和磷酸钙的水性浆料并干燥这样的浆料以产生颗粒产物来获得。 与相同组分的干物理混合物相比，共加工产品表现出改进的紧密性。

公开(公告)号：US20110151014A1

公开(公告)日：2011-06-23

申请号：US12962992

申请日：2010-12-08

申请人： Gregory Thoorens ,  Bruno LeClercq ,  Thomas Ruszkay

发明人： Gregory Thoorens ,  Bruno LeClercq ,  Thomas Ruszkay

IPC分类号： A61K9/14 ,  A61K47/38 ,  A61K31/341 ,  A61P43/00 ,  B02C17/00

CPC分类号： A61K31/341 ,  A61K9/2009 ,  A61K9/2054 ,  A61K9/2095

摘要： Coprocessed compositions containing microcrystalline cellulose and calcium carbonate, wherein the weight ratio of microcrystalline cellulose to calcium carbonate is relatively high, are useful as excipients in the preparation of solid dosage forms containing active pharmaceutical ingredients, particularly those prepared by processes involving multiple compaction steps. Such compositions may be obtained, for example, by preparing aqueous slurries or wet masses of microcrystalline cellulose and calcium carbonate and drying such slurries or wet masses to produce particulate products. The coprocessed products exhibit improved recompactibility, as compared to coprocessed products having lower microcrystalline cellulose:calcium carbonate weight ratios or as compared to physical dry blends of the two excipients.

摘要翻译： 包含微晶纤维素和碳酸钙的共加工组合物，其中微晶纤维素与碳酸钙的重量比相对较高，可用作制备含有活性药物成分的固体剂型的赋形剂，特别是通过涉及多次压实步骤的方法制备的那些。 这样的组合物可以通过例如制备水性浆液或湿块微晶纤维素和碳酸钙并干燥这样的浆料或湿块以产生颗粒产物来获得。 与具有较低微晶纤维素的共加工产物：碳酸钙重量比或与两种赋形剂的物理干混合物相比，共加工产品显示出改善的再压缩性。

公开(公告)号：US08632819B2

公开(公告)日：2014-01-21

申请号：US12962992

申请日：2010-12-08

申请人： Gregory Thoorens ,  Bruno LeClercq ,  Thomas Ruszkay

发明人： Gregory Thoorens ,  Bruno LeClercq ,  Thomas Ruszkay

IPC分类号： A61K9/16 ,  A61K9/20 ,  A61K47/38 ,  G01N3/08

CPC分类号： A61K31/341 ,  A61K9/2009 ,  A61K9/2054 ,  A61K9/2095

摘要： Coprocessed compositions containing microcrystalline cellulose and calcium carbonate, wherein the weight ratio of microcrystalline cellulose to calcium carbonate is relatively high, are useful as excipients in the preparation of solid dosage forms containing active pharmaceutical ingredients, particularly those prepared by processes involving multiple compaction steps. Such compositions may be obtained, for example, by preparing aqueous slurries or wet masses of microcrystalline cellulose and calcium carbonate and drying such slurries or wet masses to produce particulate products. The coprocessed products exhibit improved recompactibility, as compared to coprocessed products having lower microcrystalline cellulose:calcium carbonate weight ratios or as compared to physical dry blends of the two excipients.

摘要翻译： 包含微晶纤维素和碳酸钙的共加工组合物，其中微晶纤维素与碳酸钙的重量比相对较高，可用作制备含有活性药物成分的固体剂型的赋形剂，特别是通过涉及多次压实步骤的方法制备的那些。 这样的组合物可以通过例如制备水性浆液或湿块微晶纤维素和碳酸钙并干燥这样的浆料或湿块以产生颗粒产物来获得。 与具有较低微晶纤维素的共加工产物：碳酸钙重量比或与两种赋形剂的物理干混合物相比，共加工产品显示出改善的再压缩性。

公开(公告)号：US20110104271A1

公开(公告)日：2011-05-05

申请号：US12917991

申请日：2010-11-02

申请人： Gregory Thoorens ,  Bruno LeClercq ,  Thomas Ruszkay

发明人： Gregory Thoorens ,  Bruno LeClercq ,  Thomas Ruszkay

IPC分类号： A61K9/00 ,  A61K31/375 ,  A61K9/20

CPC分类号： A61K31/375 ,  A61K9/2009 ,  A61K9/2054 ,  A61K47/02 ,  A61K47/38

摘要： Compositions containing calcium phosphate and microcrystalline cellulose are useful as excipients in the preparation of solid dosage forms containing active pharmaceutical ingredients, particularly those prepared by processes involving multiple compaction steps. The recompactibility performance of such compositions is improved through the use of calcium phosphate having a relatively small particle size, e.g., a median particle size of not more than about 20 microns or not more than about 10 microns.

摘要翻译： 含有磷酸钙和微晶纤维素的组合物可用作制备含有活性药物成分的固体剂型的赋形剂，特别是通过涉及多次压实步骤的方法制备的那些。 通过使用具有相对较小粒度的磷酸钙，例如不大于约20微米或不大于约10微米的中值粒度，可以改善这种组合物的可再现性能。