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公开(公告)号：US20140079786A1
公开(公告)日：2014-03-20
申请号：US14031781
申请日：2013-09-19
发明人： Susan Freers , Carrie Shipley , Brian Jensen , Shawn Engels
CPC分类号： A61K47/46 , A23L7/115 , A23L29/35 , A23L33/21 , A23L33/22 , A61K9/1676 , A61K31/192
摘要： The disclosure pertains generally to spheres made from a fiber source. These spheres may be used as cores for carrying other ingredients or may be used alone for applications in the food, pharmaceutical, nutraceutical, personal care, and industrial industries. In many embodiments the ingredients used in this invention are derived from a natural resource, and are safe to ingest. In some embodiments, the spheres are formed using a centrifugal tumbling-granulating-coating apparatus.
摘要翻译： 本公开一般涉及由纤维源制成的球体。 这些球体可以用作承载其他成分的核心，或者可以单独用于食品，制药，保健品，个人护理和工业工业中的应用。 在许多实施方案中，本发明中使用的成分来自天然资源，并且是安全的摄取。 在一些实施例中，使用离心滚筒造粒涂布装置形成球体。
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公开(公告)号：US20130071479A1
公开(公告)日：2013-03-21
申请号：US13623591
申请日：2012-09-20
发明人： Susan Freers , Carrie Shipley , Brian Jensen , Shawn Engels
CPC分类号： A61K9/5078 , A61K9/1652 , A61K9/5036 , Y10T428/2989
摘要： The disclosure relates to substantially uniform, high density microspheres and methods of making the microspheres. The microspheres can be made to be small in size with a narrow range of particle size distribution and a high sphericity. In one aspect, the microspheres provided herein are provided in the form of spherical cores comprising maltodextrin or maltodextrin and starch and are prepared using a centrifugal tumbling-granulating-coating apparatus. In another aspect, the spherical cores can be powder-coated with one or more layers of small particles, such as starch particles. The microspheres provided herein can be used as cores for multi-particulate solid dosage delivery systems as well as other pharmaceutical, nutraceutical, food, personal care, and other applications.
摘要翻译： 本公开涉及基本均匀的高密度微球体和制备微球体的方法。 微球可以制成尺寸小，粒径分布窄，球形度高。 在一个方面，本文提供的微球以包含麦芽糖糊精或麦芽糖糊精和淀粉的球形芯的形式提供，并且使用离心转鼓造粒包衣设备制备。 另一方面，球形芯可以粉末涂覆一层或多层小颗粒，如淀粉颗粒。 本文提供的微球可用作多颗粒固体剂量递送系统的核心，以及其它药物，保健食品，食品，个人护理和其它应用。
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公开(公告)号：US09918942B2
公开(公告)日：2018-03-20
申请号：US13623591
申请日：2012-09-20
发明人： Susan Freers , Carrie Shipley , Brian Jensen , Shawn Engels
CPC分类号： A61K9/5078 , A61K9/1652 , A61K9/5036 , Y10T428/2989
摘要： The disclosure relates to substantially uniform, high density microspheres and methods of making the microspheres. The microspheres can be made to be small in size with a narrow range of particle size distribution and a high sphericity. In one aspect, the microspheres provided herein are provided in the form of spherical cores comprising maltodextrin or maltodextrin and starch and are prepared using a centrifugal tumbling-granulating-coating apparatus. In another aspect, the spherical cores can be powder-coated with one or more layers of small particles, such as starch particles. The microspheres provided herein can be used as cores for multi-particulate solid dosage delivery systems as well as other pharmaceutical, nutraceutical, food, personal care, and other applications.
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