公开(公告)号：US20190125680A1

公开(公告)日：2019-05-02

申请号：US16225418

申请日：2018-12-19

申请人： Grünenthal GmbH

发明人： Sebastian SCHWIER ,  Marcel HAUPTS ,  Lutz BARNSCHEID ,  Jana PÄTZ

IPC分类号： A61K9/20 ,  A61K31/135 ,  A61K31/137 ,  A61K31/138

摘要： The invention relates to a tamper-resistant tablet comprising (i) a matrix material in an amount of more than one third of the total weight of the tablet; and (ii) a plurality of coated particulates in an amount of less than two thirds of the total weight of the tablet; wherein said particulates comprise a pharmacologically active compound and a physiologically acceptable polymer, preferably a polyalkylene oxide; and form a discontinuous phase within the matrix material; which preferably provides under in vitro conditions immediate release of the pharmacologically active compound in accordance with Ph. Eur.; and method of using said tablet to treat pain and other conditions.