公开(公告)号：US20240067746A1

公开(公告)日：2024-02-29

申请号：US18175905

申请日：2023-02-28

申请人： GlycoNex Inc.

发明人： Tong-Hsuan CHANG ,  Mei-Chun YANG ,  Liahng-Yirn LIU ,  Jerry TING ,  Shu-Yen CHANG ,  Yen-Ying CHEN ,  Yu-Yu LIN ,  Shu-Lun TANG

IPC分类号： C07K16/28 ,  A61K47/65 ,  A61K47/68 ,  A61K49/00 ,  A61K51/10 ,  C12N15/85

CPC分类号： C07K16/2896 ,  A61K47/65 ,  A61K47/6801 ,  A61K49/0058 ,  A61K51/1048 ,  C12N15/85 ,  C07K2317/565 ,  C12N2015/8518

摘要： Disclosed herein are humanized antibodies, antigen-binding fragments thereof, and antibody conjugates, that are capable of specifically binding to certain biantennary Lewis antigens, which antigens are expressed in a variety of cancers. The presently disclosed antibodies are useful to target antigen-expressing cells for treatment or detection of disease, including various cancers. Also provided are polynucleotides, vectors, and host cells for producing the disclosed antibodies and antigen-binding fragments thereof. Pharmaceutical compositions, methods of treatment and detection, and uses of the antibodies, antigen-binding fragments, antibody conjugates, and compositions are also provided.

公开(公告)号：US20220403042A1

公开(公告)日：2022-12-22

申请号：US17815117

申请日：2022-07-26

申请人： GlycoNex Inc.

发明人： Tong-Hsuan CHANG ,  Mei-Chun YANG ,  Liahng-Yirn LIU ,  Jerry TING ,  Shu-Yen CHANG ,  Yen-Ying CHEN ,  Yu-Yu LIN ,  Shu-Lun TANG

IPC分类号： C07K16/28 ,  A61K47/65 ,  A61K47/68 ,  A61K49/00 ,  A61K51/10 ,  C12N15/85

摘要： Disclosed herein are humanized antibodies, antigen-binding fragments thereof, and antibody conjugates, that are capable of specifically binding to certain biantennary Lewis antigens, which antigens are expressed in a variety of cancers. The presently disclosed antibodies are useful to target antigen-expressing cells for treatment or detection of disease, including various cancers. Also provided are polynucleotides, vectors, and host cells for producing the disclosed antibodies and antigen-binding fragments thereof. Pharmaceutical compositions, methods of treatment and detection, and uses of the antibodies, antigen-binding fragments, antibody conjugates, and compositions are also provided.