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1.发明申请FUSION PROTEINS COMPRISING PDGF AND VEGF BINDING PORTIONS AND METHODS OF USING THEREOF 有权包含PDGF和VEGF结合部分的融合蛋白及其使用方法公开(公告)号：US20140315804A1
公开(公告)日：2014-10-23
申请号：US14210354
申请日：2014-03-13
Applicant: GENZYME CORPORATION
Inventor： Peter PECHAN , Jeffery ARDINGER , Hillard RUBIN , Samuel WADSWORTH , Abraham SCARIA
IPC: C07K14/71
CPC classification number: C07K14/71 , A61K38/00 , C07K2319/30 , C07K2319/70 , C12N2510/02 , C12N2750/14143
Abstract: The present provides fusion proteins comprising PDGF and VEGF binding portions, and recombinant viral particles encoding the fusion proteins. Compositions comprising the fusion proteins and viral particles as well as methods of using the same are also provided.
Abstract translation: 本发明提供了包含PDGF和VEGF结合部分的融合蛋白，以及编码融合蛋白的重组病毒颗粒。 还提供了包含融合蛋白和病毒颗粒的组合物以及其使用方法。
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公开(公告)号：US20220340883A1
公开(公告)日：2022-10-27
申请号：US17686245
申请日：2022-03-03
Applicant: Genzyme Corporation
Inventor： Peter PECHAN , Jeffery ARDINGER , Abraham SCARIA , Samuel WADSWORTH
IPC: C12N7/00
Abstract: The use of iNOS inhibitors, including aurintricarboxylic acid, dexamethasone and valproic acid, to increase the yield of a variety of viruses in culture, including recombinant herpesviruses is described.
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Patent Agency Ranking
公开(公告)号：US20220064262A1
公开(公告)日：2022-03-03
申请号：US17367027
申请日：2021-07-02
Applicant: Genzyme Corporation
Inventor： Peter PECHAN , Jeffery ARDINGER , Hillard RUBIN , Samuel WADSWORTH , Abraham SCARIA
Abstract: The present provides fusion proteins comprising PDGF and VEGF binding portions, and recombinant viral particles encoding the fusion proteins. Compositions comprising the fusion proteins and viral particles as well as methods of using the same are also provided.
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4.发明申请公开(公告)号：US20160068844A1
公开(公告)日：2016-03-10
申请号：US14785159
申请日：2014-04-17
Applicant: GENZYME CORPORATION , THE UNITED STATES OF AMERICA,AS REPRESENTED BY THE SECRETARY,DEPARTMENT OF HEALTH AND HUMAN SERVICE
Inventor： Samuel WADSWORTH , Abraham SCARIA , Chi-Chao CHAN
IPC: C12N15/113
CPC classification number: C12N15/1136 , A61K38/1793 , C07K14/7155 , C07K2319/30 , C12N2750/14143
Abstract: Compositions and methods for treating macular degeneration are disclosed. The methods utilize IL17 inhibitors, such as IL17 receptors, as well as fusion proteins including an IL17 receptor fused with a multimerization domain, and recombinant viral vectors encoding such fusions.
Abstract translation: 公开了治疗黄斑变性的组合物和方法。 所述方法利用IL17抑制剂，例如IL17受体，以及融合蛋白，包括与多聚化结构域融合的IL17受体，以及编码这种融合物的重组病毒载体。
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公开(公告)号：US20210040484A1
公开(公告)日：2021-02-11
申请号：US16835913
申请日：2020-03-31
Applicant: Genzyme Corporation , The United States of America, as Represented by the Secretary, Department of Health and Human Servic
Inventor： Samuel WADSWORTH , Abraham SCARIA , Chi-Chao CHAN
IPC: C12N15/113 , A61K38/17 , C07K14/715
Abstract: Compositions and methods for treating macular degeneration are disclosed. The methods utilize IL17 inhibitors, such as IL17 receptors, as well as fusion proteins including an IL17 receptor fused with a multimerization domain, and recombinant viral vectors encoding such fusions.
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公开(公告)号：US20180230490A1
公开(公告)日：2018-08-16
申请号：US15858303
申请日：2017-12-29
Applicant: Genzyme Corporation
Inventor： Catherine O'RIORDAN , Samuel WADSWORTH
CPC classification number: C12N15/86 , A61K38/1709 , A61K48/005 , A61K48/0075 , C07K2319/00 , C12N2750/14143 , C12N2750/14145 , C12N2810/6027 , C12N2830/002 , C12N2830/15
Abstract: This disclosure provides methods and compositions for treating disorders or injuries that affect motor function and control in a subject. In one aspect, the invention a transgene product is delivered to a subject's spinal cord by administering a recombinant viral vector containing the transgene to the spinal cord. The viral vector delivers the transgene which expresses the encoded recombinant viral gene product. The viral gene product comprises HIF1-alpha. Also provided are compositions for delivery of a transgene product to a subject's spinal cord.
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7.发明申请公开(公告)号：US20170342127A1
公开(公告)日：2017-11-30
申请号：US15471725
申请日：2017-03-28
Applicant: Genzyme Corporation
Inventor： Peter PECHAN , Jeffery ARDINGER , Hillard RUBIN , Samuel WADSWORTH , Abraham SCARIA
CPC classification number: C07K14/71 , A61K38/00 , C07K2319/30 , C07K2319/70 , C12N2510/02 , C12N2750/14143
Abstract: The present provides fusion proteins comprising PDGF and VEGF binding portions, and recombinant viral particles encoding the fusion proteins. Compositions comprising the fusion proteins and viral particles as well as methods of using the same are also provided.
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