公开(公告)号：US20240279220A1

公开(公告)日：2024-08-22

申请号：US18593686

申请日：2024-03-01

Applicant: Genzyme Corporation

Inventor： Junkai Liao ,  Mark Munson ,  Sukanthini Thurairatnam ,  Bradford Hirth ,  Zhongli Gao ,  Gregory Hurlbut ,  David Borcherding ,  Matthieu Barrague ,  Timothy Alan Gillespy ,  Alexandre Gross ,  Andrew Good ,  Roy Vaz ,  Jinyu Liu ,  Yi Li ,  Markus Metz ,  Anatoly Ruvinsky ,  Claude Barberis

IPC: C07D417/14 ,  A61K31/404 ,  A61K31/4155 ,  A61K31/4178 ,  A61K31/4196 ,  A61K31/422 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/675 ,  C07D401/14 ,  C07D403/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/12 ,  C07D417/12 ,  C07F9/6503

CPC classification number: C07D417/14 ,  A61K31/404 ,  A61K31/4155 ,  A61K31/4178 ,  A61K31/4196 ,  A61K31/422 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/675 ,  C07D401/14 ,  C07D403/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/12 ,  C07D417/12 ,  C07F9/65031

Abstract: The invention relates to heterocyclic compounds, pharmaceutically acceptable salts thereof, and pharmaceutical preparations thereof. Also described herein are compositions and the use of such compounds in methods of treating diseases and conditions mediated by deficient CFTR activity, in particular cystic fibrosis.

公开(公告)号：US20240217991A1

公开(公告)日：2024-07-04

申请号：US18404409

申请日：2024-01-04

Applicant: GENZYME CORPORATION

Inventor： John L. Kane, JR. ,  Claude Barberis ,  Mark Czekaj ,  Paul Erdman ,  Barret Giese ,  Michael Kothe ,  Tieu-Binh Le ,  Jinyu Liu ,  Liang Ma ,  Markus Metz ,  Vinod Patel ,  Andrew Scholte ,  Patrick Shum ,  Linli Wei

IPC: C07D519/00 ,  A61P37/06 ,  C07D405/06 ,  C07D471/04 ,  C07D487/04

CPC classification number: C07D519/00 ,  A61P37/06 ,  C07D405/06 ,  C07D471/04 ,  C07D487/04

Abstract: Compounds of the formulas




which are useful as colony stimulating factor-1 receptor inhibitors (“CSF-1R inhibitors”).

公开(公告)号：US11274108B2

公开(公告)日：2022-03-15

申请号：US15745223

申请日：2016-07-19

Applicant: Genzyme Corporation

Inventor： John L. Kane, Jr. ,  Claude Barberis ,  Mark Czekaj ,  Paul Erdman ,  Barret Giese ,  Michael Kothe ,  Tieu-Binh Le ,  Jinyu Liu ,  Liang Ma ,  Markus Metz ,  Vinod Patel ,  Andrew Scholte ,  Patrick Wai-Kwok Shum ,  Linli Wei

IPC: C07D519/00 ,  C07D471/04 ,  C07D405/06 ,  C07D487/04 ,  A61P37/06

Abstract: Compounds of the formulas which are useful as colony stimulating factor-1 receptor inhibitors (“CSF-1R inhibitors”).

公开(公告)号：US20220396588A1

公开(公告)日：2022-12-15

申请号：US17668209

申请日：2022-02-09

Applicant: Genzyme Corporation

Inventor： John L. Kane, JR. ,  Claude Barberis ,  Mark Czekaj ,  Paul Erdman ,  Barret Giese ,  Michael Kothe ,  Tieu-Binh Le ,  Jinyu Liu ,  Liang Ma ,  Markus Metz ,  Vinod Patel ,  Andrew Scholte ,  Patrick Shum ,  Linli Wei

IPC: C07D519/00 ,  C07D405/06 ,  C07D471/04 ,  C07D487/04 ,  A61P37/06

Abstract: Compounds of the formulas which are useful as colony stimulating factor-1 receptor inhibitors (“CSF-1R inhibitors”).

公开(公告)号：US20190016707A1

公开(公告)日：2019-01-17

申请号：US15745223

申请日：2016-07-19

Applicant: Genzyme Corporation

Inventor： John L. KANE, Jr. ,  Claude Barberis ,  Mark Czekaj ,  Paul Erdman ,  Barret Giese ,  Michael Kothe ,  Tieu-Binh Le ,  Jinyu Liu ,  Liang Ma ,  Markus Metz ,  Vinod Patel ,  Andrew Scholte ,  Patrick Wai-Kwok Shum ,  Linli Wei

IPC: C07D405/04 ,  C07D405/06 ,  C07D471/04 ,  C07D487/04 ,  C07D519/00 ,  A61P37/06

Abstract: Compounds of the formulas which are useful as colony stimulating factor-1 receptor inhibitors (“CSF-1R inhibitors”).