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![Solid forms of 3-((1R,3R)-1-(2,6-difluoro-4-((1-(3- fluoropropyl)azetidin-3-yl)amino)phenyl)-3-methyl-1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indol-2-yl)-2,2-difluoropropan-1-ol and processes for preparing fused tricyclic compounds comprising a substituted phenyl or pyridinyl moiety, including methods of their use](/abs-image/US/2021/03/23/US10954234B2/abs.jpg.150x150.jpg)
公开(公告)号：US10954234B2
公开(公告)日：2021-03-23
申请号：US16443515
申请日：2019-06-17
Applicant: Genentech, Inc. , Hoffman-La Roche, Inc.
Inventor： Cheol Keun Chung , Jie Xu , Hans Iding , Kyle Clagg , Michael Dalziel , Alec Fettes , Francis Gosselin , Ngiap-Kie Lim , Andrew McClory , Haiming Zhang , Paroma Chakravarty , Karthik Nagapudi , Sarah Robinson
IPC: C07D471/04 , C07D403/14 , A61P35/00 , A61P35/04
Abstract: Provided herein are solid forms, salts, and formulations of 3-((1R,3R)-1-(2,6-difluoro-4-((1-(3-fluoropropyl)azetidin-3-yl)amino)phenyl)-3-methyl-1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indol-2-yl)-2,2-difluoropropan-1-ol, processes and synthesis thereof, and methods of their use in the treatment of cancer.
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Patent Agency Ranking
公开(公告)号：US12071422B2
公开(公告)日：2024-08-27
申请号：US18164302
申请日：2023-02-03
Applicant: Genentech, Inc. , Hoffmann-La Roche Inc.
Inventor： Rene Lebl , Ngiap Kie Lim , Roland Christoph Meier , Ugo Jonathan Orcel , Joerg Sedelmeier , Jeff Shen , Lauren Elizabeth Sirois , Jacob C. Timmerman , Etienne Trachsel , Nicholas Andrew White , Jie Xu , Haiming Zhang , Stephan Bachmann , Thomas Michael Bass , Raphael Bigler , Johannes Adrian Burkhard , Kyle Bradley Pascual Clagg , Francis Gosselin , Chong Han , Dainis Kaldre , Sean M. Kelly , Sebastian Herold , Christian Leitner
IPC: C07D401/04 , B01J23/44 , B01J23/755
CPC classification number: C07D401/04 , B01J23/44 , B01J23/755
Abstract: Provided herein are methods to synthesize compounds useful in the treatment of cancer where such compounds comprise a quinazolinyl core moiety and at least one stereoisomeric or atropisomeric moiety.
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![Solid forms of 3-((1R,3R)-1-(2,6-difluoro-4-((1-(3-fluoropropyl)azetidin-3- yl)amino)phenyl)-3-methyl-1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indol-2-yl)-2,2-difluoropropan-1-ol and processes for preparing fused tricyclic compounds comprising a substituted phenyl or pyridinyl moiety, including methods of their use](/abs-image/US/2023/10/10/US11780834B2/abs.jpg.150x150.jpg)
公开(公告)号：US11780834B2
公开(公告)日：2023-10-10
申请号：US17110607
申请日：2020-12-03
Applicant: Hoffmann-La Roche Inc. , GENENTECH, INC.
Inventor： Cheol Keun Chung , Jie Xu , Hans Iding , Kyle Clagg , Michael Dalziel , Alec Fettes , Francis Gosselin , Ngiap-Kie Lim , Andrew McClory , Haiming Zhang , Paroma Chakravarty , Karthik Nagapudi , Sarah Robinson
IPC: C07D471/04 , C07D403/14
CPC classification number: C07D471/04 , C07D403/14 , C07B2200/13
Abstract: Provided herein are solid forms, salts, and formulations of 3-((1R,3R)-1-(2,6-difluoro-4-((1-(3-fluoropropyl)azetidin-3-yl)amino)phenyl)-3-methyl-1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indol-2-yl)-2,2-difluoropropan-1-ol, processes and synthesis thereof, and methods of their use in the treatment of cancer.
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公开(公告)号：US20220081413A1
公开(公告)日：2022-03-17
申请号：US17398345
申请日：2021-08-10
Applicant: Genentech, Inc. , Hoffmann-La Roche Inc.
Inventor： Ngiap-Kie Lim , Jeff Shen , Lauren E. Sirois , Jacob C. Timmerman , Etienne Trachsel , Nicholas A. White , Jie Xu , Haiming Zhang , Stephan Bachmann , Raphael Bigler , Kyle Bradley Pascual Clagg , Antonio Dipasquale , Francis Gosselin , Ugo Jonathan Orcel , Roland Christoph Meier
IPC: C07D401/14
Abstract: Provided herein are methods of synthesizing quinazoline compounds comprising at least one atropisomeric center.
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5.发明授权公开(公告)号：US11873305B2
公开(公告)日：2024-01-16
申请号：US17360593
申请日：2021-06-28
Applicant: Genentech, Inc. , Hoffmann-La Roche Inc.
Inventor： Haiming Zhang , Jie Xu , Georg Wuitschik , Remy Angelaud , Sebastian Herold , Alfred Stutz , Tobias Bruetsch , Johannes Burkhard
IPC: C07D209/10 , C07D487/04
CPC classification number: C07D487/04
Abstract: Provided herein are processes for the preparation of indolyl intermediates using Wenker Synthesis for the total synthesis of SERD compounds useful in the treatment of cancer.
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公开(公告)号：US12172982B2
公开(公告)日：2024-12-24
申请号：US17398345
申请日：2021-08-10
Applicant: Genentech, Inc. , Hoffmann-La Roche Inc.
Inventor： Ngiap-Kie Lim , Jeff Shen , Lauren Elizabeth Sirois , Jacob C. Timmerman , Etienne Trachsel , Nicholas Andrew White , Jie Xu , Haiming Zhang , Stephan Bachmann , Raphael Bigler , Kyle Bradley Pascual Clagg , Antonio Giovanni Dipasquale , Francis Gosselin , Ugo Jonathan Orcel , Roland Christoph Meier
IPC: C07D401/04 , C07D401/14
Abstract: Provided herein are methods of synthesizing quinazoline compounds comprising at least one atropisomeric center.
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