公开(公告)号：US20200055896A1

公开(公告)日：2020-02-20

申请号：US16589740

申请日：2019-10-01

Applicant: GENENTECH, INC.

Inventor： Travis William BAINBRIDGE ,  James Andrew ERNST ,  Junichiro SONODA

IPC: C07K7/06 ,  C07K16/40 ,  G01N33/573 ,  G01N33/542 ,  A61K49/00 ,  A61K47/68 ,  C12Q1/37

Abstract: Fluorescence resonance energy transfer (FRET) constructs comprising donor and acceptor fluorophore moieties, and a peptide linking the two, which is a substrate of the endopeptidase fibroblast activation protein (FAP). Also provided are isolated nucleic acids expressing the construct, cell lines comprising the nucleic acids, and kits comprising the construct. Further provided are methods of detecting FAP using the construct via FRET.

公开(公告)号：US20230279067A1

公开(公告)日：2023-09-07

申请号：US18057604

申请日：2022-11-21

Applicant: Genentech, Inc.

Inventor： Yichin LIU ,  Christine Carine MOUSSION ,  Travis William BAINBRIDGE ,  lraj HOSSEINI ,  Gregory Alan LAZAR ,  Sivan COHEN ,  Christopher Charles KEMBALL ,  Jill M. SCHARTNER

IPC: C07K14/475 ,  A61K31/713 ,  A61K38/18 ,  A61K39/395 ,  C07K16/28

CPC classification number: C07K14/475 ,  A61K31/713 ,  A61K38/18 ,  A61K39/39541 ,  C07K16/2818 ,  C07K16/2827 ,  A61K2039/505

Abstract: The invention provides an effectorless immunoglobulin Fc protein, fusions of the effectorless Fc protein to a Flt3 ligand, and methods of using the same.

公开(公告)号：US20220289803A1

公开(公告)日：2022-09-15

申请号：US17664589

申请日：2022-05-23

Applicant: Genentech, Inc.

Inventor： Yichin LIU ,  Christine Carine MOUSSION ,  Travis William BAINBRIDGE ,  Iraj HOSSEINI ,  Gregory Alan LAZAR ,  Sivan COHEN ,  Christopher Charles KEMBALL ,  Jill M. SCHARTNER

IPC: C07K14/475 ,  A61K38/18 ,  A61K31/713 ,  A61K39/395 ,  C07K16/28

Abstract: The invention provides an effectoriess immunoglobulin Fc protein, fusions of the effectorless Fc protein to a Flt3 ligand, and methods of using the same.