公开(公告)号：US20180057500A1

公开(公告)日：2018-03-01

申请号：US15690140

申请日：2017-08-29

Applicant: Genentech, Inc.

Inventor： Roland J BILLEDEAU ,  James J. CRAWFORD ,  Saul JAIME-FIGUEROA ,  Wendy LEE ,  Francisco Javier LOPEZ-TAPIA ,  Sung-Sau SO

IPC: C07D487/04 ,  A61K31/4985 ,  A61K45/06 ,  C07D401/14 ,  A61K31/502 ,  C07D471/14 ,  A61K31/496

CPC classification number: C07D487/04 ,  A61K31/496 ,  A61K31/4985 ,  A61K31/502 ,  A61K31/5025 ,  A61K31/519 ,  A61K45/06 ,  C07D401/14 ,  C07D405/14 ,  C07D471/04 ,  C07D471/14 ,  C07D519/00 ,  A61K2300/00

Abstract: Pyrazole carboxamide compounds of Formula I are provided, with various substituents, and including stereoisomers, tautomers, and pharmaceutically acceptable salts thereof, useful for inhibiting Btk, and for treating cancer and immune disorders such as inflammation mediated by Btk. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, and treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.