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公开(公告)号：US08895729B2
公开(公告)日：2014-11-25
申请号：US14049477
申请日：2013-10-09
Applicant: Genentech, Inc.
Inventor： Srinivasan Babu , Zhigang Cheng , Francis Gosselin , Pirmin Hidber , Ursula Hoffmann , Theresa Humphries , Reinhard Reents , Qingping Tian , Herbert Yajima
IPC: C07D495/04 , C07D295/185 , C07D491/00
CPC classification number: C07D495/04 , C07D295/185
Abstract: Process methods for making the dual mTOR/PI3K inhibitor GDC-0980, named as (S)-1-(4-((2-(2-aminopyrimidin-5-yl)-7-methyl-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxypropan-1-one, having the structure: and stereoisomers, geometric isomers, tautomers, and pharmaceutically acceptable salts thereof.
Abstract translation: 制备双重mTOR / PI3K抑制剂GDC-0980的方法，命名为（S）-1-（4 - （（2-（2-氨基嘧啶-5-基）-7-甲基-4-吗啉代噻吩并[3,2 d]嘧啶-6-基）甲基）哌嗪-1-基）-2-羟基丙-1-酮，其具有以下结构：立体异构体，几何异构体，互变异构体及其药学上可接受的盐。
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Patent Agency Ranking
公开(公告)号：US20140100366A1
公开(公告)日：2014-04-10
申请号：US14049477
申请日：2013-10-09
Applicant: Genentech, Inc.
Inventor： Srinivasan Babu , Zhigang Cheng , Francis Gosselin , Pirmin Hidber , Ursula Hoffmann , Theresa Humphries , Reinhard Reents , Qingping Tian , Herbert Yajima
IPC: C07D495/04 , C07D295/185
CPC classification number: C07D495/04 , C07D295/185
Abstract: Process methods for making the dual mTOR/PI3K inhibitor GDC-0980, named as (S)-1-(4-((2-(2-aminopyrimidin-5-yl)-7-methyl-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxypropan-1-one, having the structure: and stereoisomers, geometric isomers, tautomers, and pharmaceutically acceptable salts thereof.
Abstract translation: 制备双重mTOR / PI3K抑制剂GDC-0980的方法，命名为（S）-1-（4 - （（2-（2-氨基嘧啶-5-基）-7-甲基-4-吗啉代噻吩并[3,2 d]嘧啶-6-基）甲基）哌嗪-1-基）-2-羟基丙-1-酮，其具有以下结构：立体异构体，几何异构体，互变异构体及其药学上可接受的盐。
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公开(公告)号：US20250009749A1
公开(公告)日：2025-01-09
申请号：US18605258
申请日：2024-03-14
Applicant: Genentech, Inc.
Inventor： Reinhard Reents , Pirmin Hidber , Andre Hell , Peter Steidle , Martin Wunderlich , Marie Pepelnjak , Francis Gosselin , Edward Yost
IPC: A61K31/517 , A61K9/20 , A61K9/28
Abstract: The present invention relates to pharmaceutical compositions comprising Akt protein kinase inhibitors with therapeutic activity against diseases such as cancer as well as processes for their preparation and their use as medicament.
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公开(公告)号：US11969426B2
公开(公告)日：2024-04-30
申请号：US17724045
申请日：2022-04-19
Applicant: Genentech, Inc.
Inventor： Reinhard Reents , Pirmin Hidber , Andre Hell , Peter Steidle , Martin Wunderlich , Marie Pepelnjak , Francis Gosselin , Edward Yost
IPC: A61K31/517 , A61K9/20 , A61K9/28
CPC classification number: A61K31/517 , A61K9/2009 , A61K9/2018 , A61K9/2027 , A61K9/2054 , A61K9/2059 , A61K9/2077 , A61K9/2095 , A61K9/28 , A61K9/284
Abstract: The present invention relates to pharmaceutical compositions comprising Akt protein kinase inhibitors with therapeutic activity against diseases such as cancer as well as processes for their preparation and their use as medicament.
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公开(公告)号：US20220241279A1
公开(公告)日：2022-08-04
申请号：US17724045
申请日：2022-04-19
Applicant: Genentech, Inc.
Inventor： Reinhard Reents , Pirmin Hidber , Andre Hell , Peter Steidle , Martin Wunderlich , Marie Pepelnjak , Francis Gosselin , Edward Yost
IPC: A61K31/517 , A61K9/20 , A61K9/28
Abstract: The present invention relates to pharmaceutical compositions comprising Akt protein kinase inhibitors with therapeutic activity against diseases such as cancer as well as processes for their preparation and their use as medicament.
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公开(公告)号：US11337977B2
公开(公告)日：2022-05-24
申请号：US15672505
申请日：2017-08-09
Applicant: Genentech, Inc.
Inventor： Reinhard Reents , Pirmin Hidber , Andre Hell , Peter Steidle , Martin Wunderlich , Marie Pepelnjak , Francis Gosselin , Edward Yost
IPC: A61K31/517 , A61K9/20 , A61K9/28
Abstract: The present invention relates to pharmaceutical compositions comprising Akt protein kinase inhibitors with therapeutic activity against diseases such as cancer as well as processes for their preparation and their use as medicament.
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