公开(公告)号：US20240043553A1

公开(公告)日：2024-02-08

申请号：US18338985

申请日：2023-06-21

Applicant: Genentech, Inc. ,  Hoffmann-La Roche Inc.

Inventor： Andrea KNAPP ,  Chi-Chung LI ,  Enkhtsetseg PUREV ,  Michael C. WEI

IPC: C07K16/28 ,  A61K31/4412 ,  A61K31/573 ,  A61K45/06 ,  A61P35/00

CPC classification number: C07K16/2887 ,  C07K16/2809 ,  A61K31/4412 ,  A61K31/573 ,  A61K45/06 ,  A61P35/00 ,  A61K2039/505

Abstract: The present invention relates to the treatment of subjects having previously untreated follicular lymphoma (FL). More specifically, the invention pertains to the treatment of subjects having previously untreated FL by administering a combination of mosunetuzumab and lenalidomide.

公开(公告)号：US20220153842A1

公开(公告)日：2022-05-19

申请号：US17516979

申请日：2021-11-02

Applicant: Genentech, Inc.

Inventor： Chi-Chung LI ,  Carol Elaine O'HEAR ,  Stephen James SIMKO, III ,  Iris Tranthuyngan TO ,  Klara TOTPAL ,  Hong WANG ,  Michael C. WEI ,  Shen YIN ,  Brendan Christian BENDER ,  Xi CHEN ,  Yu-Waye CHU ,  Maria HRISTOPOULOS

IPC: C07K16/28 ,  C07K16/46 ,  A61K47/68 ,  A61P35/00

Abstract: The present invention relates to the treatment of subjects having CD20-positive cell proliferative disorders (e.g., B cell proliferative disorders, such as non-Hodgkin's lymphomas). More specifically, the invention pertains to the treatment of subjects having a CD20-positive cell proliferative disorder (e.g., B cell proliferative disorder) by administering a combination of an anti-CD20/anti-CD3 bispecific antibody and an anti-CD79b antibody drug conjugate.