公开(公告)号：US20200331968A1

公开(公告)日：2020-10-22

申请号：US16816969

申请日：2020-03-12

Applicant: Genentech, Inc.

Inventor： Emily J. HANAN ,  Georgette CASTANEDO ,  Marie Gabrielle BRAUN ,  Keira GARLAND ,  Peter Andrew SMITH ,  Richard PASTOR ,  Paul GIBBONS ,  Yunxing CHENG ,  Guosheng WU ,  Yuhong FU ,  Po-Wai YUEN

IPC: C07K11/02

Abstract: Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of lipoprotein signal peptidase II (LspA), a key protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.