公开(公告)号：US20240094194A1

公开(公告)日：2024-03-21

申请号：US18518715

申请日：2023-11-24

Applicant: Genentech, Inc.

Inventor： Claudio CIFERRI ,  Evan Michael Green ,  Marc Kschonsak

IPC: G01N33/50 ,  G01N33/569

CPC classification number: G01N33/5091 ,  G01N33/56994 ,  C12N2503/00 ,  G01N2333/045 ,  G01N2469/10

Abstract: Provided herein are methods of treating or preventing human cytomegalovirus (HCMV) infection comprising modulating interactions between the HCMV gH/gL/UL128-131A pentamer and plasma membrane-expressed host cell proteins, as well as methods of identifying modulators of such interactions.

公开(公告)号：US20250164502A1

公开(公告)日：2025-05-22

申请号：US18515382

申请日：2023-11-21

Applicant: Genentech, Inc. ,  University of Copenhagen

Inventor： Cameron L. Noland ,  Jian Mehr-Dean Payandeh ,  Stephan Alexander Pless ,  Han Chow Chua ,  Marc Kschonsak

IPC: G01N33/68 ,  C07K14/47

Abstract: The present disclosure relates to mutant human NaX ion channel (“NaX”) proteins and screening methods using a mutant human NaX that may be used to identify molecules that modulate the activity of human NaX. For example, in some embodiments, screening methods involve performing an ion channel assay on a mutant human NaX in the presence of a potential NaX modulator. The disclosure also relates to molecules that act as modulators of human NaX and associated kits for detecting such molecules.

公开(公告)号：US20240295565A1

公开(公告)日：2024-09-05

申请号：US18405256

申请日：2024-01-05

Applicant: Genentech Inc. ,  University of Copenhagen

Inventor： Jian Mehr-Dean Payandeh ,  Stephan Alexander Pless ,  Han Chow Chua ,  Marc Kschonsak

IPC: G01N33/68 ,  C07K14/47 ,  G01N33/557

CPC classification number: G01N33/6872 ,  C07K14/47 ,  G01N33/557

Abstract: The present disclosure relates, inter alia, to complexes of the Na+ leak channel non-selective protein (NALCN) with FAM155A (also called FAM155; Family with sequence similarity 155 member A), UNC79 (uncoordinated 79), and UNC80 (uncoordinated 80), methods of screening for molecules that modulate the activity of the complex, and identified modulators thereof.