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公开(公告)号：US20210309660A1
公开(公告)日：2021-10-07
申请号：US16858004
申请日：2020-04-24
Applicant: Genentech, Inc.
Inventor： Nicole Blaquiere , Peter Dragovich , Lewis J. Gazzard , Thomas Pillow , Steven T. Staben , Binqing Wei , Jianfeng Xin
IPC: C07D471/16 , C07D493/10 , C07D403/04 , C07D417/14 , C07D413/14 , A61P35/00
Abstract: The present disclosure relates to bifunctional compounds, which can be used as modulators of targeted ubiquitination. In particular, the present disclosure is directed to compounds which contain on one end a VHL ligand moiety, which binds to the VHL E3 ubiquitin ligase, and on the other end a moiety that binds a target protein such that degradation of the target protein/polypeptide is effectuated. Also disclosed are VHL ligands.
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公开(公告)号：US20250042919A1
公开(公告)日：2025-02-06
申请号：US18882588
申请日：2024-09-11
Applicant: Genentech, Inc.
Inventor： Lewis J. Gazzard , Samantha Alyson Green , Matthew Leo Landry , Sushant Malhotra , Michael Siu , Steven Do , Yun-Xing Cheng , Limin Cheng , Jianfeng Xin , Mingtao He
IPC: C07D498/22 , A61K31/553 , A61K45/06 , A61P35/00 , C07D519/00
Abstract: Provided herein are tetracyclic oxazepinyl compounds useful in the treatment on cancers.
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公开(公告)号：US12084429B2
公开(公告)日：2024-09-10
申请号：US17644993
申请日：2021-12-17
Applicant: Genentech, Inc.
Inventor： Sushant Malhotra , Jianfeng Xin , Steven Do , Jack Terrett
IPC: C07D401/04 , A61K9/00 , A61K31/517 , A61P35/00 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D471/14
CPC classification number: C07D401/14 , A61K9/0019 , A61K9/0053 , A61P35/00 , C07D405/14
Abstract: This invention pertains to fused ring compounds of Formula (I), as further detailed herein, which are used for the inhibition of Ras proteins, as well as compositions comprising these compounds and methods of treatment by their administration.
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公开(公告)号：US20230089126A1
公开(公告)日：2023-03-23
申请号：US17644993
申请日：2021-12-17
Applicant: Genentech, Inc.
Inventor： Sushant Malhotra , Jianfeng Xin , Steven Do , Jack Terrett
IPC: C07D401/14 , A61P35/00 , A61K9/00 , C07D405/14
Abstract: This invention pertains to fused ring compounds of Formula (I), as further detailed herein, which are used for the inhibition of Ras proteins, as well as compositions comprising these compounds and methods of treatment by their administration.
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Patent Agency Ranking
公开(公告)号：US20210230142A9
公开(公告)日：2021-07-29
申请号：US16679104
申请日：2019-11-08
Applicant: Genentech, Inc.
Inventor： Sushant Malhotra , Jianfeng Xin , Steven Do , Jack Terrett
IPC: C07D401/14 , C07D405/14 , A61P35/00 , A61K9/00
Abstract: This invention pertains to fused ring compounds of Formula (I), as further detailed herein, which are used for the inhibition of Ras proteins, as well as compositions comprising these compounds and methods of treatment by their administration.
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公开(公告)号：US20250059163A1
公开(公告)日：2025-02-20
申请号：US18747054
申请日：2024-06-18
Applicant: Genentech, Inc.
Inventor： Sushant Malhotra , Jianfeng Xin , Steven Do , Jack Terrett
IPC: C07D401/14 , A61K9/00 , A61P35/00 , C07D405/14
Abstract: This invention pertains to fused ring compounds of Formula (I), as further detailed herein, which are used for the inhibition of Ras proteins, as well as compositions comprising these compounds and methods of treatment by their administration.
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公开(公告)号：US11242344B2
公开(公告)日：2022-02-08
申请号：US16858004
申请日：2020-04-24
Applicant: Genentech, Inc.
Inventor： Nicole Blaquiere , Peter Dragovich , Lewis J. Gazzard , Thomas Pillow , Steven T. Staben , Binqing Wei , Jianfeng Xin
IPC: C07D471/16 , C07D493/10 , A61P35/00 , C07D417/14 , C07D413/14 , C07D403/04
Abstract: The present disclosure relates to bifunctional compounds, which can be used as modulators of targeted ubiquitination. In particular, the present disclosure is directed to compounds which contain on one end a VHL ligand moiety, which binds to the VHL E3 ubiquitin ligase, and on the other end a moiety that binds a target protein such that degradation of the target protein/polypeptide is effectuated. Also disclosed are VHL ligands.
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公开(公告)号：US11236068B2
公开(公告)日：2022-02-01
申请号：US16679104
申请日：2019-11-08
Applicant: Genentech, Inc.
Inventor： Sushant Malhotra , Jianfeng Xin , Steven Do , Jack Terrett
IPC: A61K31/517 , A61K31/519 , A61P35/00 , C07D401/14 , C07D403/14 , C07D407/14 , C07D471/04 , A61K9/00 , C07D405/14
Abstract: This invention pertains to fused ring compounds of Formula (I), as further detailed herein, which are used for the inhibition of Ras proteins, as well as compositions comprising these compounds and methods of treatment by their administration.
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公开(公告)号：US20200181118A1
公开(公告)日：2020-06-11
申请号：US16679104
申请日：2019-11-08
Applicant: Genentech, Inc.
Inventor： Sushant Malhotra , Jianfeng Xin
IPC: C07D401/14 , C07D405/14 , A61P35/00 , A61K9/00
Abstract: This invention pertains to fused ring compounds of Formula (I), as further detailed herein, which are used for the inhibition of Ras proteins, as well as compositions comprising these compounds and methods of treatment by their administration.
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