公开(公告)号：US20030166020A1

公开(公告)日：2003-09-04

申请号：US10192022

申请日：2002-07-10

Applicant: Genentech, Inc.

Inventor： Edward T. Cox ,  Jennie P. Mather ,  Mary B. Sliwkowski ,  Teresa K. Woodruff

IPC: G01N033/53 ,  G01N033/567 ,  C07H021/04 ,  C12P021/02 ,  C12N005/06 ,  C07K014/705

CPC classification number: C07K14/71 ,  C07K14/51 ,  C07K14/575

Abstract: An isolated TGF-null supergene family (TSF) receptor polypeptide is provided. This polypeptide preferably is an inhibin/activin receptor polypeptide and has at least 75% sequence identity with the mature human inhibin/activin receptor sequence. Also provided is a method for purifying TGF-null supergene family members such as inhibin or activin using the polypeptide, and a method for screening for compounds with TGF-null supergene family member activity by contacting the compound with the polypeptide and detecting if binding has occurred and the compound is active.