公开(公告)号：US20230257430A1

公开(公告)日：2023-08-17

申请号：US18309003

申请日：2023-04-28

Applicant: Genentech, Inc.

Inventor： Jason LIANG ,  Avinashnarayan VENKATANARAYAN ,  Lai Man Phu YEE ,  Donald Scott KIRKPATRICK

IPC: C07K14/47 ,  G01N33/68 ,  C12N9/12

CPC classification number: C07K14/4702 ,  G01N33/6848 ,  C12Y207/12002 ,  C12N9/12 ,  G01N2458/15

Abstract: Provided herein are recombinant proteins comprising sets of polypeptides that may be used for measurement of protein levels.

公开(公告)号：US20240109958A1

公开(公告)日：2024-04-04

申请号：US18537389

申请日：2023-12-12

Applicant: Genentech, Inc.

Inventor： Donald Scott KIRKPATRICK ,  James Thomas KOERBER ,  Christopher Williamson DAVIES

IPC: C07K16/18 ,  C07K16/00 ,  C40B30/04 ,  G01N33/68

CPC classification number: C07K16/18 ,  C07K16/005 ,  C40B30/04 ,  G01N33/6845 ,  C07K2317/20 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622

Abstract: Provided herein are antibodies that bind to a peptide of an N-terminally ubiquitinated polypeptide and methods of screening for such antibodies. Also provided herein are detection and enrichment methods using such antibodies for detecting or enriching a peptide of an N-terminally ubiquitinated polypeptide.