公开(公告)号：US20240043831A1

公开(公告)日：2024-02-08

申请号：US18120020

申请日：2023-03-10

Applicant: Genentech, Inc.

Inventor： Devin TESAR ,  Xiaocheng CHEN ,  Mark DENNIS ,  Isidro HOTZEL

IPC: C12N15/10 ,  C12N15/70 ,  C12N15/85 ,  C12P21/02 ,  C07K16/00 ,  C12N15/74

CPC classification number: C12N15/1037 ,  C12N15/70 ,  C12N15/85 ,  C12P21/02 ,  C07K16/00 ,  C12N15/74 ,  C07K2319/02 ,  C07K2319/40 ,  C07K2319/735 ,  C12N2820/10 ,  C12N2820/55 ,  C12N2820/85 ,  C12N2830/42 ,  C12N2830/55 ,  C12N2830/85

Abstract: The invention provides an expression and secretion system, and methods of using the same, for the expression and secretion of one fusion protein in prokaryotic cells and a second fusion protein in eukaryotic cells. Also provided herein are nucleic acid molecules, vectors and host cells comprising such vectors and nucleic acid molecules.

公开(公告)号：US20170369869A1

公开(公告)日：2017-12-28

申请号：US15690544

申请日：2017-08-30

Applicant: Genentech, Inc.

Inventor： Devin TESAR ,  Xiaocheng CHEN ,  Mark DENNIS ,  Isidro HOTZEL

IPC: C12N15/10 ,  C12N15/74 ,  C12P21/02 ,  C12N15/70 ,  C12N15/85 ,  C07K16/00

CPC classification number: C12N15/1037 ,  C07K16/00 ,  C07K2319/02 ,  C07K2319/40 ,  C07K2319/735 ,  C12N15/70 ,  C12N15/74 ,  C12N15/85 ,  C12N2820/10 ,  C12N2820/55 ,  C12N2820/85 ,  C12N2830/42 ,  C12N2830/55 ,  C12N2830/85 ,  C12P21/02

Abstract: The invention provides an expression and secretion system, and methods of using the same, for the expression and secretion of one fusion protein in prokaryotic cells and a second fusion protein in eukaryotic cells. Also provided herein are nucleic acid molecules, vectors and host cells comprising such vectors and nucleic acid molecules.