公开(公告)号：US20250054630A1

公开(公告)日：2025-02-13

申请号：US18929474

申请日：2024-10-28

Applicant: Genentech, Inc.

Inventor： Cleopatra KOZLOWSKI ,  Daniel RUDERMAN

IPC: G16H50/20 ,  G16B15/00 ,  G16H10/60

Abstract: A method for image-based hepatocellular carcinoma (HCC) molecular subtype classification may include determining, within an image depicting a plurality of cells of a biological sample, a plurality of tiles with each tile depicting a portion of the plurality of cells comprising the sample. A machine learning model may be applied to determine a molecular subtype for the portion of the plurality of cells depicted in each tile. Moreover, an overall molecular subtype for the plurality of cells depicted in the image of the biological sample may be determined based on the molecular subtype of the portion of the plurality of cells depicted in each tile of the plurality of tiles. For example, another machine learning model may be applied to determine the overall molecular subtype of the plurality of cells depicted in the image of the biological sample. Related systems and computer program products are also provided.