公开(公告)号：US20040018980A1

公开(公告)日：2004-01-29

申请号：US10461060

申请日：2003-06-13

Applicant: Genentech, Inc.

Inventor： Austin L. Gurney ,  Caroline Hebert ,  William J. Henzel ,  Rhona Kabakoff ,  David L. Shelton ,  Daniel B. Tumas

IPC: A61K038/17

CPC classification number: C07K14/4703 ,  A61K38/00 ,  A61K39/00 ,  C12N2799/026

Abstract: The present invention is directed to novel polypeptides, designated FIZZ, which are secreted low molecular weight molecules showing no significant sequence homology to any known protein, and nucleic acid sequences encoding such proteins. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptide of the present invention fused to heterologous polypeptide sequences, and antibodies which bind to the polypeptides of the present invention. Methods of using FIZZ polypeptides to treat various neurotrophin-related conditions are further provided.

Abstract translation: 本发明涉及称为FIZZ的新型多肽，其是分泌的低分子量分子，与任何已知蛋白质没有显着的序列同源性，以及编码这种蛋白质的核酸序列。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明多肽的嵌合多肽分子，以及结合本发明多肽的抗体。 进一步提供使用FIZZ多肽治疗各种神经营养因子相关病症的方法。

公开(公告)号：US20020192209A1

公开(公告)日：2002-12-19

申请号：US10001054

申请日：2001-11-30

Applicant: GENENTECH, INC.

Inventor： Kevin P. Baker ,  Audrey Goddard ,  Austin L. Gurney ,  Caroline Hebert ,  William Henzel ,  Rhona C. Kabakoff ,  David L. Shelton ,  Victoria Smith ,  Colin K. Watanabe ,  William I. Wood

IPC: A61K039/395 ,  C07H021/04 ,  C12N009/00 ,  C07K016/30 ,  C12P021/02 ,  C12N005/06

CPC classification number: A61K39/395 ,  C07H21/04 ,  C07K16/30 ,  C12N5/06 ,  C12N9/00 ,  C12P21/02

Abstract: The present invention concerns methods and compositions for inhibiting neoplastic cell growth. In particular, the present invention concerns antitumor compositions and methods for the treatment of tumors. The invention further concerns screening methods for identifying growth inhibitory, e.g., antitumor compounds. The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

Abstract translation: 本发明涉及用于抑制肿瘤细胞生长的方法和组合物。 特别地，本发明涉及用于治疗肿瘤的抗肿瘤组合物和方法。 本发明还涉及用于鉴定生长抑制性例如抗肿瘤化合物的筛选方法。 本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。