公开(公告)号：US20040005598A1

公开(公告)日：2004-01-08

申请号：US10392190

申请日：2003-03-19

Applicant: Genentech, Inc.

Inventor： Brigitte DeVaux ,  David Eberhard ,  Audrey Goddard ,  Paul J. Godowski ,  J. Christopher Grimaldi ,  Kenneth J. Hillan ,  Colin K. Watanabe ,  William I. Wood ,  Daniel Yansura ,  Zemin Zhang

IPC: C12Q001/68 ,  G01N033/574 ,  C07H021/04 ,  C12N009/64 ,  C07K016/30 ,  C12P021/02 ,  C12N005/06

CPC classification number: C07K14/705 ,  A61K47/6455 ,  C07K16/30 ,  C07K16/40 ,  C12N9/0091

Abstract: The present invention is directed to novel polypeptides Protein Upregulated in Metastatic Prostate Cancer (PUMPCn) and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

Abstract translation: 本发明涉及在转移前列腺癌（PUMPCn）中上调的新型多肽蛋白质和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。