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公开(公告)号：USRE49129E1
公开(公告)日：2022-07-12
申请号：US16455104
申请日：2019-06-27
IPC分类号： A61K38/40 , A61K31/295 , A61K45/06 , A61K31/164 , A61K31/4704 , A61K31/16 , A61K31/198 , A61K31/4196 , A61K31/4412 , A61K31/223 , A61K31/426 , A61K31/472 , A61P39/04 , A61P9/10 , A61P25/28
摘要： The present invention relates to methods of treatment of Hypoxia Inducible Factor (HIF)-related conditions, and in particular to methods of treatment of HIF-related conditions comprising the administration of a composition comprising transferrins.
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公开(公告)号：US11208471B2
公开(公告)日：2021-12-28
申请号：US16745563
申请日：2020-01-17
发明人： Thomas Barnett , David A. Ross
摘要： Compositions and methods of the present invention prevent, inhibit or reduce the toxic effects of proteins and toxins secreted from microbes. A method for neutralizing microbial protein products in a subject comprises administering a composition to the subject, said composition comprising plasma-derived IgM and optionally one or more excipients in a pharmaceutical carrier, wherein the composition is administered in an amount effective to neutralize the microbial protein products.
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3.发明申请公开(公告)号：US20200223908A1
公开(公告)日：2020-07-16
申请号：US16745563
申请日：2020-01-17
发明人： Thomas Barnett , David A. Ross
IPC分类号： C07K16/12 , A61K31/407 , A61K38/14 , A61K38/17 , A61K39/40
摘要： Compositions and methods of the present invention prevent, inhibit or reduce the toxic effects of proteins and toxins secreted from microbes. A method for neutralizing microbial protein products in a subject comprises administering a composition to the subject, said composition comprising plasma-derived IgM and optionally one or more excipients in a pharmaceutical carrier, wherein the composition is administered in an amount effective to neutralize the microbial protein products.
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公开(公告)号：US10660956B2
公开(公告)日：2020-05-26
申请号：US16456689
申请日：2019-06-28
发明人： Thomas Barnett , David A. Ross
IPC分类号： A61K39/00 , A61K39/40 , C07K16/00 , A01K67/027 , C07K16/12
摘要： Embodiments of the present invention provide methods for the treatment or prevention of infection-related immune conditions using compositions comprising IgM.
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5.发明申请公开(公告)号：US20180153991A1
公开(公告)日：2018-06-07
申请号：US15883486
申请日：2018-01-30
发明人： Thomas Barnett , David A. Ross
IPC分类号： A61K39/40 , C07K16/00 , A01K67/027
CPC分类号： A61K39/40 , A01K67/0275 , C07K16/00 , C07K16/1214 , C07K16/1228 , C07K16/1232 , C07K16/1282 , C07K2317/52 , C07K2317/70 , C07K2317/73 , C07K2317/76
摘要： Embodiments of the present invention provide methods for the treatment or prevention of infection-related immune conditions using compositions comprising IgM.
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6.发明申请公开(公告)号：US20200237912A1
公开(公告)日：2020-07-30
申请号：US16849083
申请日：2020-04-15
发明人： Thomas Barnett , David A. Ross
IPC分类号： A61K39/40 , C07K16/12 , C07K16/00 , A01K67/027
摘要： Embodiments of the present invention provide methods for the treatment or prevention of infection-related immune conditions using compositions comprising IgM.
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7.发明申请METHOD FOR TREATING INFECTIOUS DISEASES USING A COMPOSITION COMPRISING PLASMA-DERIVED IMMUNOGLOBULIN M (IgM) 审中-公开使用包含等离子体衍生的免疫球蛋白M（IgM）的组合物治疗感染性疾病的方法公开(公告)号：US20170037115A1
公开(公告)日：2017-02-09
申请号：US15156562
申请日：2016-05-17
发明人： Thomas Barnett , David A. Ross
IPC分类号： C07K16/12 , A61K38/17 , A61K31/407 , A61K39/40 , A61K38/14
CPC分类号： C07K16/1282 , A61K31/407 , A61K38/14 , A61K38/1741 , A61K39/40 , A61K2039/545 , C07K16/12 , C07K16/1214 , C07K16/1232 , C07K16/1271 , C07K2317/52 , C07K2317/76
摘要： Compositions and methods of the present invention prevent, inhibit or reduce the toxic effects of proteins and toxins secreted from microbes. A method for neutralizing microbial protein products in a subject comprises administering a composition to the subject, said composition comprising plasma-derived IgM and optionally one or more excipients in a pharmaceutical carrier, wherein the composition is administered in an amount effective to neutralize the microbial protein products.
摘要翻译： 本发明的组合物和方法防止，抑制或降低由微生物分泌的蛋白质和毒素的毒性作用。 用于中和受试者中的微生物蛋白质产物的方法包括向受试者施用组合物，所述组合物包含血浆源IgM和任选的一种或多种药物载体中的赋形剂，其中所述组合物以有效中和微生物蛋白质的量 产品。
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8.发明申请METHOD OF TREATMENT OF HYPOXIA INDUCIBLE FACTOR (HIF)-RELATED CONDITIONS 有权治疗HYPOXIA诱导因子（HIF）相关条件的方法公开(公告)号：US20160008437A1
公开(公告)日：2016-01-14
申请号：US14754883
申请日：2015-06-30
IPC分类号： A61K38/40 , A61K31/4704 , A61K31/164
CPC分类号： A61K38/40 , A61K31/16 , A61K31/164 , A61K31/198 , A61K31/223 , A61K31/4196 , A61K31/426 , A61K31/4412 , A61K31/4704 , A61K31/472 , A61K45/06 , A61P9/10 , A61P25/28 , A61P39/04 , A61K2300/00
摘要： The present invention relates to methods of treatment of Hypoxia Inducible Factor (HIF)-related conditions, and in particular to methods of treatment of HIF-related conditions comprising the administration of a composition comprising transferrins.
摘要翻译： 本发明涉及治疗缺氧诱导因子（HIF）相关病症的方法，特别涉及治疗HIF相关病症的方法，包括施用包含转移蛋白的组合物。
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9.发明申请METHOD FOR THE TREATMENT OR PREVENTION OF INFECTION-RELATED IMMUNE CONDITIONS USING A COMPOSITION COMPRISING IGM 有权使用包含IGM的组合物治疗或预防感染相关免疫条件的方法公开(公告)号：US20170035882A1
公开(公告)日：2017-02-09
申请号：US15147226
申请日：2016-05-05
发明人： Thomas Barnett , David A. Ross
CPC分类号： A61K39/40 , A01K67/0275 , C07K16/00 , C07K16/1214 , C07K16/1228 , C07K16/1232 , C07K16/1282 , C07K2317/52 , C07K2317/70 , C07K2317/73 , C07K2317/76
摘要： Embodiments of the present invention provide methods for the treatment or prevention of infection-related immune conditions using compositions comprising IgM.
摘要翻译： 本发明的实施方案提供使用包含IgM的组合物治疗或预防感染相关免疫病症的方法。
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10.发明授权公开(公告)号：US10570194B2
公开(公告)日：2020-02-25
申请号：US15156562
申请日：2016-05-17
发明人： Thomas Barnett , David A. Ross
摘要： Compositions and methods of the present invention prevent, inhibit or reduce the toxic effects of proteins and toxins secreted from microbes. A method for neutralizing microbial protein products in a subject comprises administering a composition to the subject, said composition comprising plasma-derived IgM and optionally one or more excipients in a pharmaceutical carrier, wherein the composition is administered in an amount effective to neutralize the microbial protein products.
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