公开(公告)号：US3926957A

公开(公告)日：1975-12-16

申请号：US46678074

申请日：1974-05-03

Applicant: GLAXO LAB LTD

Inventor： GREGSON MICHAEL ,  COOK MARTIN CHRISTOPHER ,  GREGORY GORDON IAN

IPC: C07C259/02 ,  C07D307/54 ,  C07D333/24 ,  C07D499/70 ,  C07D499/44

CPC classification number: C07D307/54 ,  C07C259/02 ,  C07D333/24

Abstract: WHERE R is a hydrogen atom or an organic group and Ra is a hydrogen atom or an acyl group. The compounds are syn isomers or exist as mixtures containing at least 75% of the syn isomer. These antibiotic compounds possess high antibacterial activity against a range of gram positive and gram negative organisms coupled with particularly high stability to Beta -lactamases produced by various gram negative organisms. The invention is also concerned with the administration of the compounds.

The invention provides novel antibiotic compounds which are 6 Beta -acylamidopenam-3-carboxylic acids and non-toxic derivatives thereof, characterized in that the acylamido group has the structure