公开(公告)号：US09340556B2

公开(公告)日：2016-05-17

申请号：US14349754

申请日：2012-10-04

Applicant: GLAXO GROUP LIMITED ,  SHIONOGI & CO., LTD

Inventor： Xiangmin Liao ,  Neil David Pearson ,  Israil Pendrak ,  Masayuki Sano

IPC: A61K31/546 ,  C07D501/60 ,  C07D501/56

CPC classification number: C07D501/60 ,  A61K31/546 ,  C07D501/56 ,  Y02A50/473 ,  Y02A50/481

Abstract: The present invention relates to cephalosporin antibacterial compounds of Formula (I): or corresponding pharmaceutically acceptable salts thereof, corresponding pharmaceutical compositions, compound preparation and treatment methods for bacterial infections, especially those caused by gram-negative bacteria.

Abstract translation: 本发明涉及式（I）的头孢菌素抗菌化合物：或其相应的药学上可接受的盐，相应的药物组合物，细菌感染的化合物制备和治疗方法，特别是由革兰氏阴性菌引起的那些。

公开(公告)号：US20140249126A1

公开(公告)日：2014-09-04

申请号：US14349754

申请日：2012-10-04

Applicant: GLAXO GROUP LIMITED ,  Shionogi & Co., Ltd.

Inventor： Xiangmin Liao ,  Neil David Pearson ,  Israil Pendrak ,  Masayuki Sano

IPC: C07D501/60

CPC classification number: C07D501/60 ,  A61K31/546 ,  C07D501/56 ,  Y02A50/473 ,  Y02A50/481

Abstract: The present invention relates to cephalosporin antibacterial compounds of Formula (I): or corresponding pharmaceutically acceptable salts thereof, corresponding pharmaceutical compositions, compound preparation and treatment methods for bacterial infections, especially those caused by gram-negative bacteria.

Abstract translation: 本发明涉及式（I）的头孢菌素抗菌化合物：或其相应的药学上可接受的盐，相应的药物组合物，细菌感染的化合物制备和治疗方法，特别是由革兰氏阴性菌引起的那些。

公开(公告)号：US10174053B2

公开(公告)日：2019-01-08

申请号：US15490220

申请日：2017-04-18

Applicant: Glaxo Group Limited ,  Shionogi and Co., Ltd

Inventor： Toshiaki Aoki ,  Hiroki Kusano ,  Xiangmin Liao ,  Neil David Pearson ,  Israil Pendrak ,  Jun Sato ,  Reema K. Thalji ,  Kenji Yamawaki ,  Katsuki Yokoo

IPC: C07D501/48 ,  C07D505/24 ,  C07D501/50 ,  A61K9/00

Abstract: The compounds of the subject invention are related to 2-substituted cephem compounds, which have a wide antimicrobial spectrum, in particular exhibit potent antimicrobial activity against beta-lactamase producing Gram negative bacteria, and pharmaceutical compositions comprising the same.