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公开(公告)号：US20160025828A1
公开(公告)日：2016-01-28
申请号：US14774750
申请日：2014-03-14
CPC分类号： G01R33/4806 , A61B5/0042 , A61B5/055 , A61B5/4088 , A61B5/4839 , A61B2576/026
摘要： Provided herein are methods related to identifying an early, asymptomatic (prodromal) stage of a neurodegenerative disease or identifying a subject with a symptomatic neurodegenerative disease, including, for example, mild cognitive impairment (MCI), Alzheimer's Disease (AD), or HIV-associated neurocognitive disorder (HAND), using functional MRI data from the subject. Methods are also provided for treating a subject identified with the methods taught herein and for modifying or selecting treatment based on the results of fMRI. Methods are also available for staging neurodegenerative disease and for identifying agents useful in treating them.
摘要翻译： 本文提供了与鉴定神经变性疾病的早期，无症状（前驱）阶段或鉴定具有症状性神经变性疾病的受试者相关的方法，包括例如轻度认知障碍（MCI），阿尔茨海默病（AD）或HIV- 相关的神经认知障碍（HAND），使用受试者的功能性MRI数据。 还提供了用于治疗用本文教导的方法鉴定的受试者并且基于fMRI的结果修改或选择治疗的方法。 方法还可用于分期神经变性疾病和用于鉴定可用于治疗它们的药剂。
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公开(公告)号：US10534052B2
公开(公告)日：2020-01-14
申请号：US14774750
申请日：2014-03-14
摘要： Provided herein are methods related to identifying an early, asymptomatic (prodromal) stage of a neurodegenerative disease or identifying a subject with a symptomatic neurodegenerative disease, including, for example, mild cognitive impairment (MCI), Alzheimer's Disease (AD), or HIV-associated neurocognitive disorder (HAND), using functional MRI data from the subject. Methods are also provided for treating a subject identified with the methods taught herein and for modifying or selecting treatment based on the results of fMRI. Methods are also available for staging neurodegenerative disease and for identifying agents useful in treating them.
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