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公开(公告)号：US20140255381A1
公开(公告)日：2014-09-11
申请号：US14030725
申请日：2013-09-18
申请人： GENZYME CORPORATION
发明人： Elyse BOURQUE , Cassandra CELATKA , Bradford HIRTH , Markus METZ , Zhong ZHAO , Renato SKLERJ , Yibin XIANG , Katherine JANCSICS , John MARSHALL , Seng CHENG , Ronald SCHEULE , Mario CABRERA-SALAZAR , Andrew GOOD
IPC分类号： C07D453/02 , A61K38/47 , A61K31/439
CPC分类号： C07D487/08 , A61K31/439 , A61K31/454 , A61K31/46 , A61K31/506 , A61K31/551 , A61K38/47 , C07D453/00 , C07D453/02 , C07D455/02 , C12Y302/01022
摘要： The invention relates to inhibitors of glucosylceramide synthase (GCS) useful for the treatment metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, and for the treatment of cancer.
摘要翻译： 本发明涉及可用于单独或与酶替代疗法组合治疗代谢性疾病如溶酶体贮积病的葡萄糖神经酰胺合成酶（GCS）抑制剂和癌症治疗。
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公开(公告)号：US20210261557A1
公开(公告)日：2021-08-26
申请号：US17242016
申请日：2021-04-27
申请人： GENZYME CORPORATION
发明人： Elyse BOURQUE , Mario CABRERA-SALAZAR , Cassandra CELATKA , Seng CHENG , Mary A. CROMWELL , Andrew GOOD , Bradford HIRTH , Katherine JANCSICS , John P. LEONARD , Lingyun LI , James LILLIE , Hanlan LIU , Elina MAKINO , John MARSHALL , Paul MASON , Markus METZ , Fazeela MORSHED , Thomas O'SHEA , Ronald SCHEULE , Renato SKERLJ , Bing WANG , Yibin XIANG , Zhong ZHAO
IPC分类号： C07D487/08 , A61K31/439 , A61K31/454 , A61K38/47 , C07D453/02 , C07D453/00 , A61K31/46 , A61K31/506 , A61K31/551 , C07D455/02
摘要： The invention relates to inhibitors of glucosylceramide synthase (GCS) useful for the treatment of metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, and for the treatment of cancer.
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公开(公告)号：US20140371460A1
公开(公告)日：2014-12-18
申请号：US14471958
申请日：2014-08-28
申请人： Genzyme Corporation
发明人： Elyse BOURQUE , Cassandra CELATKA , Bradford HIRTH , Markus METZ , Zhong ZHAO , Renato SKLERJ , Yibin XIANG , Katherine JANCSICS , John MARSHALL , Seng CHENG , Ronald SCHEULE , Mario CABRERA-SALAZAR , Andrew GOOD
IPC分类号： C07D453/02
CPC分类号： C07D487/08 , A61K31/439 , A61K31/454 , A61K31/46 , A61K31/506 , A61K31/551 , A61K38/47 , C07D453/00 , C07D453/02 , C07D455/02 , C12Y302/01022
摘要： The invention relates to inhibitors of glucosylceramide synthase (GCS) useful for the treatment metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, and for the treatment of cancer.
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公开(公告)号：US20220073508A1
公开(公告)日：2022-03-10
申请号：US17230385
申请日：2021-04-14
申请人： Genzyme Corporation
发明人： Elyse BOURQUE , Mario A. CABRERA-SALAZAR , Cassandra CELATKA , Seng H. CHENG , Bradford HIRTH , Andrew GOOD , Katherine JANCSICS , John MARSHALL , Markus METZ , Ronald K. SCHEULE , Renato SKERLJ , Yibin XIANG , Zhong ZHAO , John LEONARD , Thomas NATOLI , Elina MAKINO , Herve HUSSON , Oxana BESKROVNAYA
IPC分类号： C07D453/02 , C07D471/08 , A61K31/439 , A61K31/496 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K45/06
摘要： The invention relates to inhibitors of glucosylceramide synthase (GCS) useful for the treatment of metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, cystic disease and for the treatment of cancer.
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公开(公告)号：US20200048266A1
公开(公告)日：2020-02-13
申请号：US16542166
申请日：2019-08-15
申请人： GENZYME CORPORATION
发明人： Elyse BOURQUE , Mario CABRERA-SALAZAR , Cassandra CELATKA , Seng CHENG , Mary A. CROMWELL , Andrew GOOD , Bradford HIRTH , Katherine JANCSICS , John P. LEONARD , Lingyun LI , James LILLIE , Hanlan LIU , Elina MAKINO , John MARSHALL , Paul MASON , Markus METZ , Fazeela MORSHED , Thomas O'SHEA , Ronald SCHEULE , Renato SKERLJ , Bing WANG , Yibin XIANG , Zhong ZHAO
IPC分类号： C07D487/08 , A61K31/439 , A61K31/454 , A61K38/47 , C07D453/02 , C07D453/00 , A61K31/46 , A61K31/506 , A61K31/551 , C07D455/02
摘要： The invention relates to inhibitors of glucosylceramide synthase (GCS) useful for the treatment of metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, and for the treatment of cancer.
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公开(公告)号：US20160207933A1
公开(公告)日：2016-07-21
申请号：US14835402
申请日：2015-08-25
申请人： GENZYME CORPORATION
发明人： Elyse BOURQUE , Mario CABRERA-SALAZAR , Cassandra CELATKA , Seng CHENG , Mary A. CROMWELL , Andrew GOOD , Bradford HIRTH , Katherine JANCSICS , John P. LEONARD , Lingyun LI , James LILLIE , Hanlan LIU , Elina MAKINO , John MARSHALL , Paul MASON , Markus METZ , Fazeela MORSHED , Thomas O'SHEA , Ronald SCHEULE , Renato SKERLJ , Bing WANG , Yibin XIANG , Zhong ZHAO
IPC分类号： C07D487/08 , A61K31/439 , A61K38/47 , A61K31/551 , C07D455/02 , A61K31/46 , C07D453/02 , A61K31/506
摘要： The invention relates to inhibitors of glucosylceramide synthase (GCS) useful for the treatment metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, and for the treatment of cancer.
摘要翻译： 本发明涉及可用于单独或与酶替代疗法组合治疗代谢性疾病如溶酶体贮积病的葡萄糖神经酰胺合成酶（GCS）抑制剂和癌症治疗。
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