公开(公告)号：US11130819B2

公开(公告)日：2021-09-28

申请号：US17228023

申请日：2021-04-12

申请人： GENMAB A/S

发明人： David Satijn ,  Esther C. W. Breij ,  Bart E. C. G. De Goeij ,  Kristel Kemper ,  Patrick Engelberts ,  Edward N. Van Den Brink ,  Rik Rademaker ,  Dennis Verzijl ,  Sjeng Horbach ,  Paul Parren

IPC分类号： C07K16/30 ,  A61P35/00 ,  C12N15/79 ,  A61K39/00

摘要： The present invention relates to antibodies binding to 5T4, including bispecific antibodies binding to 5T4 and CD3. The invention further provides pharmaceutical compositions comprising the antibodies and use of the antibodies for therapeutic and diagnostic procedures, in particular in cancer therapy.

公开(公告)号：US11970544B2

公开(公告)日：2024-04-30

申请号：US17353087

申请日：2021-06-21

申请人： GENMAB A/S

发明人： David Satijn ,  Esther C. W. Breij ,  Bart E. C. G. De Goeij ,  Kristel Kemper ,  Patrick Engelberts ,  Edward N. Van Den Brink ,  Rik Rademaker ,  Dennis Verzijl ,  Sjeng Horbach ,  Paul Parren

IPC分类号： C07K16/30 ,  A61P35/00 ,  C12N15/79 ,  A61K39/00

CPC分类号： C07K16/30 ,  A61P35/00 ,  C12N15/79 ,  A61K2039/505 ,  C07K2317/31 ,  C07K2317/51 ,  C07K2317/565

摘要： The present invention relates to antibodies binding to 5T4, including bispecific antibodies binding to 5T4 and CD3. The invention further provides pharmaceutical compositions comprising the antibodies and use of the antibodies for therapeutic and diagnostic procedures, in particular in cancer therapy.

公开(公告)号：US20230132049A1

公开(公告)日：2023-04-27

申请号：US17938523

申请日：2022-10-06

申请人： GENMAB A/S

发明人： David SATIJN ,  Patrick Engelberts ,  Kristel Kemper ,  Esther C.W. Breij ,  Simone OOSTINDIE ,  Farshid ALEMDEHY

IPC分类号： C07K16/28 ,  C12N15/63 ,  A61P35/00

摘要： The invention relates to multispecific antibodies binding to CD3 and CD30. The invention further provides pharmaceutical compositions comprising antibodies of the invention, nucleic acids encoding the antibodies, host cells that produce the antibodies, methods of producing the antibodies and uses of the antibodies, in particular for cancer therapy.

公开(公告)号：US11814437B2

公开(公告)日：2023-11-14

申请号：US17938523

申请日：2022-10-06

申请人： GENMAB A/S

发明人： David Satijn ,  Patrick Engelberts ,  Kristel Kemper ,  Esther C. W. Breij ,  Simone Oostindie ,  Farshid Alemdehy

IPC分类号： C07K16/28 ,  A61P35/00 ,  C12N15/63

CPC分类号： C07K16/2878 ,  A61P35/00 ,  C07K16/2809 ,  C12N15/63 ,  C07K2317/31 ,  C07K2317/526 ,  C07K2317/565

摘要： The invention relates to multispecific antibodies binding to CD3 and CD30. The invention further provides pharmaceutical compositions comprising antibodies of the invention, nucleic acids encoding the antibodies, host cells that produce the antibodies, methods of producing the antibodies and uses of the antibodies, in particular for cancer therapy.

公开(公告)号：US11008399B2

公开(公告)日：2021-05-18

申请号：US17077376

申请日：2020-10-22

申请人： GENMAB A/S

发明人： David Satijn ,  Esther C. W. Breij ,  Bart E. C. G. De Goeij ,  Kristel Kemper ,  Patrick Engelberts ,  Edward N. Van Den Brink ,  Rik Rademaker ,  Dennis Verzijl ,  Sjeng Horbach ,  Paul Parren

IPC分类号： C07K16/30 ,  A61P35/00 ,  C12N15/79 ,  A61K39/00

摘要： The present invention relates to antibodies binding to 5T4, including bispecific antibodies binding to 5T4 and CD3. The invention further provides pharmaceutical compositions comprising the antibodies and use of the antibodies for therapeutic and diagnostic procedures, in particular in cancer therapy.