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公开(公告)号：US09926523B2
公开(公告)日：2018-03-27
申请号：US13839409
申请日：2013-03-15
Applicant: General Electric Company
CPC classification number: C12M23/12 , C12N5/0068 , C12N2533/30 , C12N2535/10
Abstract: A carrier for growing stem cells is provided, the carrier comprises a substrate comprising one or more outer surfaces; and a hydrophilic, water soluble coating material disposed and dried on one or more of the outer surfaces. The carrier comprises one or more structured indentations on one or more of the outer surfaces, wherein the carrier has a length at least about 0.2 mm, a width at least about 0.2 mm, and a height in a range from about 0.05 mm to 1.2 mm and each of the structured indentations has a major axis in a range from about 0.1 mm to 0.5 mm, a minor axis in a range from about 0.1 mm to 0.5 mm and a depth in a range from about 0.025 mm to about 0.5 mm. A method of culturing stem cells and stromal cells using the same carrier are also provided.
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公开(公告)号：US20170011820A1
公开(公告)日：2017-01-12
申请号：US14796005
申请日：2015-07-10
Applicant: General Electric Company
Inventor： Weijun Yin , Ming Yin , David Gilles Gascoyne , Slawomir Rubinsztajn , Venkat Subramaniam Venkataramani , Daniel Qi Tan
CPC classification number: H01B7/0216 , H01B3/12 , H01B3/46 , H02K3/30 , H02K3/40 , H02K15/08 , Y02E10/725
Abstract: An insulated winding is provided, wherein the insulated winding includes (a) an electrically conductive core; (b) an electrically insulating non-porous ceramic coating disposed on the conductive core; and (c) a composite silicone coating including a plurality of electrically insulating filler particles disposed on the ceramic coating. Further, a method of making an insulated winding is also provided.
Abstract translation: 提供绝缘绕组，其中绝缘绕组包括（a）导电芯; （b）设置在导电芯上的电绝缘的无孔陶瓷涂层; 和（c）复合硅氧烷涂层，其包括设置在陶瓷涂层上的多个电绝缘填料颗粒。 此外，还提供了制造绝缘绕组的方法。
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3.发明授权Cell carrier, associated methods for making cell carrier and culturing cells using the same 有权细胞载体，用于制备细胞载体和使用其的培养细胞的相关方法公开(公告)号：US09518249B2
公开(公告)日：2016-12-13
申请号：US13839049
申请日：2013-03-15
Applicant: General Electric Company
Inventor： Brian Michael Davis , Evelina Roxana Loghin , Kenneth Roger Conway , Andrew Arthur Paul Burns , David Gilles Gascoyne
IPC: C12N5/0735 , C12N5/00
CPC classification number: C12N5/0068 , B29C37/0025 , B29C59/02 , B29C71/0081 , B29K2025/06 , B29K2105/256 , B29K2883/00 , B29L2031/712 , C12N2501/999 , C12N2533/30 , C12N2533/52 , C12N2533/54 , C12N2533/90 , C12N2535/10 , C12N2537/00 , C12N2539/10 , Y10T156/1039
Abstract: A carrier for expansion of pluripotent stem cells is provided, wherein the carrier comprises a substrate comprising one or more outer surfaces, wherein the one or more outer surfaces are modified with gas plasma treatment, and one or more structured indentations on one or more of the outer surfaces. The carrier has a length at least about 0.2 mm, a width at least about 0.2 mm, and a height in a range from about 0.05 mm to 1.2 mm and each of the structured indentations has a major axis in a range from about 0.1 mm to 0.5 mm, a minor axis in a range from about 0.1 mm to 0.5 mm and a depth in a range from about 0.025 mm to about 0.5 mm. A method of making the carrier, and culturing stromal cells using the same carrier are also provided.
Abstract translation: 提供了用于多能干细胞扩增的载体，其中所述载体包括包含一个或多个外表面的基底，其中所述一个或多个外表面用气体等离子体处理进行修饰，以及一个或多个结构化凹陷 外表面。 载体的长度至少约0.2mm，宽度至少约0.2mm，高度在约0.05mm至1.2mm的范围内，并且每个结构化凹陷的长轴在约0.1mm至 0.5mm，短轴在约0.1mm至0.5mm的范围内，深度在约0.025mm至约0.5mm的范围内。 还提供了制造载体和使用相同载体培养基质细胞的方法。
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4.发明申请CELL CARRIER, ASSOCIATED METHODS FOR MAKING CELL CARRIER AND CULTURING CELLS USING THE SAME 有权细胞载体，用于制备细胞载体和培养细胞的相关方法公开(公告)号：US20140186946A1
公开(公告)日：2014-07-03
申请号：US13839049
申请日：2013-03-15
Applicant: General Electric Company
Inventor： Brian Michael Davis , Evelina Roxana Loghin , Kenneth Roger Conway , Andrew Arthur Paul Burns , David Gilles Gascoyne
IPC: C12N5/0735
CPC classification number: C12N5/0068 , B29C37/0025 , B29C59/02 , B29C71/0081 , B29K2025/06 , B29K2105/256 , B29K2883/00 , B29L2031/712 , C12N2501/999 , C12N2533/30 , C12N2533/52 , C12N2533/54 , C12N2533/90 , C12N2535/10 , C12N2537/00 , C12N2539/10 , Y10T156/1039
Abstract: A carrier for expansion of pluripotent stem cells is provided, wherein the carrier comprises a substrate comprising one or more outer surfaces, wherein the one or more outer surfaces are modified with gas plasma treatment, and one or more structured indentations on one or more of the outer surfaces. The carrier has a length at least about 0.2 mm, a width at least about 0.2 mm, and a height in a range from about 0.05 mm to 1.2 mm and each of the structured indentations has a major axis in a range from about 0.1 mm to 0.5 mm, a minor axis in a range from about 0.1 mm to 0.5 mm and a depth in a range from about 0.025 mm to about 0.5 mm. A method of making the carrier, and culturing stromal cells using the same carrier are also provided.
Abstract translation: 提供了用于多能干细胞扩增的载体，其中所述载体包括包含一个或多个外表面的基底，其中所述一个或多个外表面用气体等离子体处理进行修饰，以及一个或多个结构化凹陷 外表面。 载体的长度至少约0.2mm，宽度至少约0.2mm，高度在约0.05mm至1.2mm的范围内，并且每个结构化凹陷的长轴在约0.1mm至 0.5mm，短轴在约0.1mm至0.5mm的范围内，深度在约0.025mm至约0.5mm的范围内。 还提供了制造载体和使用相同载体培养基质细胞的方法。
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Patent Agency Ranking
公开(公告)号：US20130210140A1
公开(公告)日：2013-08-15
申请号：US13839409
申请日：2013-03-15
Applicant: GENERAL ELECTRIC COMPANY
IPC: C12M1/32
CPC classification number: C12M23/12 , C12N5/0068 , C12N2533/30 , C12N2535/10
Abstract: A carrier for growing stem cells is provided, the carrier comprises a substrate comprising one or more outer surfaces; and a hydrophilic, water soluble coating material disposed and dried on one or more of the outer surfaces. The carrier comprises one or more structured indentations on one or more of the outer surfaces, wherein the carrier has a length at least about 0.2 mm, a width at least about 0.2 mm, and a height in a range from about 0.05 mm to 1.2 mm and each of the structured indentations has a major axis in a range from about 0.1 mm to 0.5 mm, a minor axis in a range from about 0.1 mm to 0.5 mm and a depth in a range from about 0.025 mm to about 0.5 mm. A method of culturing stem cells and stromal cells using the same carrier are also provided.
Abstract translation: 提供了用于生长干细胞的载体，载体包括包含一个或多个外表面的基底; 以及在一个或多个外表面上设置和干燥的亲水的水溶性涂层材料。 载体在一个或多个外表面上包括一个或多个结构化的凹陷，其中载体的长度至少约0.2mm，宽度至少约0.2mm，高度在约0.05mm至1.2mm 并且每个所述结构化缺口具有在约0.1mm至0.5mm的范围内的长轴，在约0.1mm至0.5mm的范围内的短轴和在约0.025mm至约0.5mm的范围内的深度。 还提供了使用相同载体培养干细胞和基质细胞的方法。
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6.发明授权Cell carrier, associated methods for making cell carrier and culturing cells using the same 有权细胞载体，用于制备细胞载体和使用其的培养细胞的相关方法公开(公告)号：US09534206B2
公开(公告)日：2017-01-03
申请号：US14461860
申请日：2014-08-18
Applicant: General Electric Company
Inventor： Brian Michael Davis , Kenneth Roger Conway , Evelina Roxana Loghin , Andrew Arthur Paul Burns , David Gilles Gascoyne , Scott Michael Miller
CPC classification number: C12N5/0696 , C12N5/0068 , C12N2533/30 , C12N2533/90 , C12N2535/10 , C12N2537/00 , Y10T156/1039
Abstract: A carrier for expansion of induced pluripotent stem cells is provided, wherein the carrier comprises a substrate comprising one or more outer surfaces, wherein the one or more outer surfaces are modified with gas plasma treatment, and one or more structured indentations on one or more of the outer surfaces. The carrier has a length at least about 0.2 mm, a width at least about 0.2 mm, and a height in a range from about 0.05 mm to 1.2 mm and each of the structured indentations has a major axis in a range from about 0.1 mm to 0.5 mm, a minor axis in a range from about 0.1 mm to 0.5 mm and a depth in a range from about 0.025 mm to about 0.5 mm. A method of making the carrier, and culturing induced pluripotent stem cells using the same carrier are also provided.
Abstract translation: 提供了用于诱导多能干细胞扩增的载体，其中所述载体包括包含一个或多个外表面的基底，其中所述一个或多个外表面用气体等离子体处理进行修饰，以及一个或多个结构化凹陷 外表面。 载体的长度至少约0.2mm，宽度至少约0.2mm，高度在约0.05mm至1.2mm的范围内，并且每个结构化凹陷的长轴在约0.1mm至 0.5mm，短轴在约0.1mm至0.5mm的范围内，深度在约0.025mm至约0.5mm的范围内。 还提供了制造载体的方法，以及使用相同的载体培养诱导的多能干细胞。
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7.发明授权公开(公告)号：US09957478B2
公开(公告)日：2018-05-01
申请号：US15345418
申请日：2016-11-07
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Brian Michael Davis , Evelina Roxana Loghin , Kenneth Roger Conway , Andrew Arthur Paul Burns , David Gilles Gascoyne
CPC classification number: C12N5/0068 , B29C37/0025 , B29C59/02 , B29C71/0081 , B29K2025/06 , B29K2105/256 , B29K2883/00 , B29L2031/712 , C12N2501/999 , C12N2533/30 , C12N2533/52 , C12N2533/54 , C12N2533/90 , C12N2535/10 , C12N2537/00 , C12N2539/10 , Y10T156/1039
Abstract: A carrier for expansion of pluripotent stem cells is provided, wherein the carrier comprises a substrate comprising one or more outer surfaces, wherein the one or more outer surfaces are modified with gas plasma treatment, and one or more structured indentations on one or more of the outer surfaces. The carrier has a length at least about 0.2 mm, a width at least about 0.2 mm, and a height in a range from about 0.05 mm to 1.2 mm and each of the structured indentations has a major axis in a range from about 0.1 mm to 0.5 mm, a minor axis in a range from about 0.1 mm to 0.5 mm and a depth in a range from about 0.025 mm to about 0.5 mm. A method of making the carrier, and culturing stromal cells using the same carrier are also provided.
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8.发明申请Cell Carrier, Associated Methods for Making Cell Carrier and Culturing Cells Using the Same 有权细胞载体，制备细胞载体和培养细胞的相关方法公开(公告)号：US20170051248A1
公开(公告)日：2017-02-23
申请号：US15345418
申请日：2016-11-07
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Brian Michael Davis , Evelina Roxana Loghin , Kenneth Roger Conway , Andrew Arthur Paul Burns , David Gilles Gascoyne
CPC classification number: C12N5/0068 , B29C37/0025 , B29C59/02 , B29C71/0081 , B29K2025/06 , B29K2105/256 , B29K2883/00 , B29L2031/712 , C12N2501/999 , C12N2533/30 , C12N2533/52 , C12N2533/54 , C12N2533/90 , C12N2535/10 , C12N2537/00 , C12N2539/10 , Y10T156/1039
Abstract: A carrier for expansion of pluripotent stem cells is provided, wherein the carrier comprises a substrate comprising one or more outer surfaces, wherein the one or more outer surfaces are modified with gas plasma treatment, and one or more structured indentations on one or more of the outer surfaces. The carrier has a length at least about 0.2 mm, a width at least about 0.2 mm, and a height in a range from about 0.05 mm to 1.2 mm and each of the structured indentations has a major axis in a range from about 0.1 mm to 0.5 mm, a minor axis in a range from about 0.1 mm to 0.5 mm and a depth in a range from about 0.025 mm to about 0.5 mm. A method of making the carrier, and culturing stromal cells using the same carrier are also provided.
Abstract translation: 提供了用于多能干细胞扩增的载体，其中所述载体包括包含一个或多个外表面的基底，其中所述一个或多个外表面用气体等离子体处理进行修饰，以及一个或多个结构化凹陷 外表面。 载体的长度至少约0.2mm，宽度至少约0.2mm，高度在约0.05mm至1.2mm的范围内，并且每个结构化凹陷的长轴在约0.1mm至 0.5mm，短轴在约0.1mm至0.5mm的范围内，深度在约0.025mm至约0.5mm的范围内。 还提供了制造载体和使用相同载体培养基质细胞的方法。
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9.发明申请CELL CARRIER, ASSOCIATED METHODS FOR MAKING CELL CARRIER AND CULTURING CELLS USING THE SAME 有权细胞载体，用于制备细胞载体和培养细胞的相关方法公开(公告)号：US20140356949A1
公开(公告)日：2014-12-04
申请号：US14461860
申请日：2014-08-18
Applicant: General Electric Company
Inventor： Brian Michael Davis , Kenneth Roger Conway , Evelina Roxana Loghin , Andrew Arthur Paul Burns , David Gilles Gascoyne , Scott Michael Miller
IPC: C12N5/074
CPC classification number: C12N5/0696 , C12N5/0068 , C12N2533/30 , C12N2533/90 , C12N2535/10 , C12N2537/00 , Y10T156/1039
Abstract: A carrier for expansion of induced pluripotent stem cells is provided, wherein the carrier comprises a substrate comprising one or more outer surfaces, wherein the one or more outer surfaces are modified with gas plasma treatment, and one or more structured indentations on one or more of the outer surfaces. The carrier has a length at least about 0.2 mm, a width at least about 0.2 mm, and a height in a range from about 0.05 mm to 1.2 mm and each of the structured indentations has a major axis in a range from about 0.1 mm to 0.5 mm, a minor axis in a range from about 0.1 mm to 0.5 mm and a depth in a range from about 0.025 mm to about 0.5 mm. A method of making the carrier, and culturing induced pluripotent stem cells using the same carrier are also provided.
Abstract translation: 提供了用于诱导多能干细胞扩增的载体，其中所述载体包括包含一个或多个外表面的基底，其中所述一个或多个外表面用气体等离子体处理进行修饰，以及一个或多个结构化凹陷 外表面。 载体的长度至少约0.2mm，宽度至少约0.2mm，高度在约0.05mm至1.2mm的范围内，并且每个结构化凹陷的长轴在约0.1mm至 0.5mm，短轴在约0.1mm至0.5mm的范围内，深度在约0.025mm至约0.5mm的范围内。 还提供了制造载体的方法，以及使用相同的载体培养诱导的多能干细胞。
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