公开(公告)号：US09042631B2

公开(公告)日：2015-05-26

申请号：US13849585

申请日：2013-03-25

Applicant: General Electric Company

Inventor： Dirk Ryan Padfield ,  Anitti Eljas Seppo ,  Yousef Ahmed Al-Kofahi

IPC: G06K9/00

CPC classification number: G06K9/00127

Abstract: The invention relates to a computer implemented method and systems for cell level fish dot counting. FISH (fluorescence in situ hybridization) dot counting is the process of enumerating chromosomal abnormalities in the cells which can be used in areas of diagnosis and cancer research. The method comprises in part overlaying images of a biological sample comprising a nuclear counterstain mask and a FISH binary mask. The FISH binary mask is extracted using a multi-level extended h-maxima or h-minima.

Abstract translation: 本发明涉及一种用于细胞水平鱼点计数的计算机实现方法和系统。 FISH（荧光原位杂交）点计数是列举可用于诊断和癌症研究领域的细胞染色体异常的过程。 该方法部分地覆盖包括核复染面罩和FISH二进制掩模的生物样品的图像。 FISH二进制掩模是使用多级扩展h最大值或h最小值提取的。

公开(公告)号：US20140205173A1

公开(公告)日：2014-07-24

申请号：US13849585

申请日：2013-03-25

Applicant: GENERAL ELECTRIC COMPANY

Inventor： Dirk Ryan Padfield ,  Anitti Eljas Seppo ,  Yousef Ahmed Al-Kofahi

IPC: G06K9/00

CPC classification number: G06K9/00127

Abstract: The invention relates to a computer implemented method and systems for cell level fish dot counting. FISH (fluorescence in situ hybridization) dot counting is the process of enumerating chromosomal abnormalities in the cells which can be used in areas of diagnosis and cancer research. The method comprises in part overlaying images of a biological sample comprising a nuclear counterstain mask and a FISH binary mask. The FISH binary mask is extracted using a multi-level extended h-maxima or h-minima.

Abstract translation: 本发明涉及一种用于细胞水平鱼点计数的计算机实现方法和系统。 FISH（荧光原位杂交）点计数是列举可用于诊断和癌症研究领域的细胞染色体异常的过程。 该方法部分地覆盖包括核复染面罩和FISH二进制掩模的生物样品的图像。 FISH二进制掩模是使用多级扩展h最大值或h最小值提取的。