公开(公告)号：US11021711B2

公开(公告)日：2021-06-01

申请号：US15838042

申请日：2017-12-11

Applicant: GENENTECH, Inc.

Inventor： Mark Lackner ,  Lukas C. Amler ,  Guy Cavet ,  Carol O'Brien ,  Ajay Pandita

IPC: C12Q1/6886 ,  C12N15/113 ,  A61K47/68

Abstract: Methods and compositions are provided to determine if a cancer is resistant to treatment with anti-mitotic agents, including treatment with T-DM1. The methods relate to determining if the ABCC3 gene is amplified and/or overexpressed in the cancer.

公开(公告)号：US20180298387A1

公开(公告)日：2018-10-18

申请号：US15838042

申请日：2017-12-11

Applicant: GENENTECH, Inc.

Inventor： Mark Lackner ,  Lukas C. Amler ,  Guy Cavet ,  Carol O'Brien ,  Ajay Pandita

IPC: C12N15/113 ,  C12Q1/6886 ,  A61K47/68

Abstract: Methods and compositions are provided to determine if a cancer is resistant to treatment with anti-mitotic agents, including treatment with T-DM1. The methods relate to determining if the ABCC3 gene is amplified and/or overexpressed in the cancer.