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公开(公告)号：US20250058114A1
公开(公告)日：2025-02-20
申请号：US18937876
申请日：2024-11-05
Applicant: GE Precision Healthcare LLC
Inventor： Christopher Michael Puleo , Jeffrey Michael Ashe , Victoria Eugenia Cotero , Michael Ernest Marino
Abstract: The subject matter of the present disclosure generally relates to techniques for neuromodulation of lymphatic tissue that include applying one or more energy pulses to a neuron of a subject, e.g., via an electrode positioned to deliver sufficient energy to the neuron, to modulate immune function. For example, an adaptive immune reflex of a subject may be modulated via neuromodulation
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公开(公告)号：US20240237966A1
公开(公告)日：2024-07-18
申请号：US18623858
申请日：2024-04-01
Applicant: GE Precision Healthcare LLC
Inventor： Christopher Michael Puleo , Jeffrey Michael Ashe , David Andrew Shoudy , Victoria Eugenia Cotero , James Enrico Sabatini
CPC classification number: A61B8/4236 , A61B8/4281 , A61N7/00 , A61N2007/0026
Abstract: Embodiments of the present disclosure relate to techniques for accurate positioning of an energy application device for neuromodulation treatment protocols. In one embodiment, a neuromodulation positioning patch is applied to a patient's skin. The energy application device is configured to couple to a frame of the neuromodulation positioning patch to position a transducer of the energy application device within an opening at a treatment position within the opening. In one embodiment, the frame is also configured to couple to a removable dock for an imaging probe that, when coupled to the removable dock and, in turn, the frame of the neuromodulation positioning patch, is configured to acquire image data through the opening to identify or verify a treatment position.
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公开(公告)号：US20240090869A1
公开(公告)日：2024-03-21
申请号：US18520180
申请日：2023-11-27
Applicant: GE Precision Healthcare LLC
Inventor： David Andrew Shoudy , Craig Patrick Galligan , Weston Blaine Griffin , Jeffrey Michael Ashe , Warren Lee , James Enrico Sabatini
CPC classification number: A61B8/4227 , A61B8/4254 , A61N7/00 , A61N2007/0026 , A61N2007/0052 , A61N2007/0078
Abstract: The present discussion relates to structures and devices to facilitate application of an ultrasound therapy beam to a target anatomic region in a replicable manner. In certain aspects, adjustable positioning structures are described that allow a general probe positioning structure to be configured for a specific patient in a manner that allows the device to be used repeatedly to target the anatomic region, even when in non-clinical settings. In other aspects, a probe positioning structure is fabricated that is specific to a respective patient anatomy, such that use of the probe positioning structure provides repeatable targeting of the target anatomic region, even when in non-clinical settings.
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公开(公告)号：US12214223B2
公开(公告)日：2025-02-04
申请号：US18189011
申请日：2023-03-23
Applicant: GE Precision Healthcare LLC
Inventor： Jeffrey Michael Ashe , Christopher Michael Puleo , Victoria Eugenia Cotero , Ying Fan , Kirk Dennis Wallace , John Frederick Graf
Abstract: The subject matter of the present disclosure generally relates to techniques for neuromodulation that include applying energy (e.g., ultrasound energy) into an internal tissue to cause tissue displacement and identifying that the tissue displacement has occurred. In one embodiment, the presence of tissue displacement is associated with a desired therapeutic or physiological outcome, such as a change in a molecule of interest.
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Patent Agency Ranking
公开(公告)号：US20240189629A1
公开(公告)日：2024-06-13
申请号：US18587341
申请日：2024-02-26
Applicant: GE Precision Healthcare LLC
Inventor： Christopher Michael Puleo , Yang Zhao , Kirk Dennis Wallace , Ying Fan , Jeffrey Michael Ashe , David Andrew Shoudy
CPC classification number: A61N7/00 , A61B8/4245 , A61B8/4254 , A61B90/361 , A61B90/37 , A61B8/4209 , A61B8/4263 , A61N2007/0026 , A61N2007/0052
Abstract: Embodiments of the present disclosure relate to techniques for facilitating personalized neuromodulation treatment protocols. In one embodiment, a predetermined treatment position of an energy application device is used to guide future treatments for the patient. In one embodiment, a position of the energy application device relative to the predetermined treatment position is determined. In one embodiment, a total dose of ultrasound energy applied to the region of interest is determined.
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公开(公告)号：US20230226380A1
公开(公告)日：2023-07-20
申请号：US18189011
申请日：2023-03-23
Applicant: GE Precision Healthcare LLC
Inventor： Jeffrey Michael Ashe , Christopher Michael Puleo , Victoria Eugenia Cotero , Ying Fan , Kirk Dennis Wallace , John Frederick Graf
CPC classification number: A61N7/00 , A61B8/485 , A61N2007/0026 , A61N2007/0082
Abstract: The subject matter of the present disclosure generally relates to techniques for neuromodulation that include applying energy (e.g., ultrasound energy) into an internal tissue to cause tissue displacement and identifying that the tissue displacement has occurred. In one embodiment, the presence of tissue displacement is associated with a desired therapeutic or physiological outcome, such as a change in a molecule of interest.
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公开(公告)号：US20230218276A1
公开(公告)日：2023-07-13
申请号：US18179834
申请日：2023-03-07
Applicant: GE Precision Healthcare LLC
Inventor： Asha Singanamalli , David Andrew Shoudy , Jeffrey Michael Ashe , Christopher Michael Puleo
CPC classification number: A61B5/0033 , A61B5/02 , A61B5/7267
Abstract: Embodiments of the present disclosure relate to techniques for neuromodulation delivery. Based on image data acquired from the subject, control parameters controlling energy application of neuromodulating energy may be dynamically changed during the course of the delivery to maintain desired characteristics of the neuromodulating energy. For example, the beam of the neuromodulating energy may be dynamically adjusted to account for movement of an organ during breathing. In another embodiment, a desired region of interest is identified within the subject based on a trained neural network and the acquired image data.
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公开(公告)号：US20240316368A1
公开(公告)日：2024-09-26
申请号：US18264316
申请日：2022-01-31
Applicant: GE Precision Healthcare LLC
CPC classification number: A61N7/02 , A61N2007/0026
Abstract: Combined neuromodulation techniques are disclosed to treat metabolic disorders. The combined neuromodulation techniques may include dual-site neuromodulation or single-site neuromodulation. In embodiments, the neuromodulation may be administered as a combined therapy with a pharmaceutical treatment.
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公开(公告)号：US20240001159A1
公开(公告)日：2024-01-04
申请号：US18467552
申请日：2023-09-14
Applicant: GE Precision Healthcare LLC
Inventor： John Frederick Graf , Christopher Michael Puleo , Jeffrey Michael Ashe , Victoria Eugenia Cotero , David Andrew Shoudy
IPC: A61N7/00
CPC classification number: A61N7/00 , A61N2007/0086 , A61N2007/0026 , A61N2007/0052
Abstract: The subject matter of the present disclosure generally relates to techniques for neuromodulation of a tissue that include applying energy (e.g., ultrasound energy) into the tissue at multiple regions of interest, concurrently or consecutively. The neuromodulation may result in tissue displacement, which may be observed through changes in one or more molecules of interest.
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