公开(公告)号：US4062826A

公开(公告)日：1977-12-13

申请号：US647890

申请日：1976-01-09

申请人： Francis Gowland Hutchinson ,  Richard George Cleveland Henbest ,  Margaret Kenley Leggett

发明人： Francis Gowland Hutchinson ,  Richard George Cleveland Henbest ,  Margaret Kenley Leggett

IPC分类号： C08G18/40 ,  C08G18/68 ,  C08L75/04 ,  C08L75/06

CPC分类号： C08G18/68 ,  C08G18/4009 ,  C08L75/04

摘要： A shaped polymeric article of a gel-polymerisate of a homogeneous mixture comprisingA. from 5% to 95% by weight of polyurethane precursors comprising at least one polyfunctional compound and at least one polyisocyanate of the structure ##STR1## where X is a divalent radical, preferably --CH.sub.2 --, said precursors being capable of forming a cross-linked polyurethane having a glass-rubber transition temperature of at least 25.degree. C, preferably at least 35.degree. C, andB. from 95% to 5% by weight of cured polyester resin precursors, comprisingI. at least one ethylenically unsaturated polyester, andIi. at least one vinyl monomer.

摘要翻译： 1.一种均匀混合物的凝胶聚合物的成型聚合物，其包含A.包含至少一种多功能化合物的聚氨酯前体的重量的5％至95％，以及至少一种结构单一的多晶型物（I），其中X是二价 自由基，优选-CH 2 - ，所述前体能够形成玻璃 - 橡胶转变温度至少为25℃，优选至少35℃和B的交联聚氨酯。从95重量％至5重量％ 固化聚酯树脂前身，包括我至少一个乙烯基不饱和聚酯，和II。 最少一个乙烯单体。

公开(公告)号：US5889110A

公开(公告)日：1999-03-30

申请号：US473303

申请日：1995-06-07

申请人： Francis Gowland Hutchinson

发明人： Francis Gowland Hutchinson

IPC分类号： A61K9/107 ,  A61K9/00 ,  A61K9/16 ,  A61K9/22 ,  A61K9/52 ,  A61K38/00 ,  A61K38/04 ,  A61K38/11 ,  A61K38/17 ,  A61K38/21 ,  A61K38/22 ,  A61K38/23 ,  A61K38/24 ,  A61K38/26 ,  A61K38/28 ,  A61K38/35 ,  A61K38/43 ,  A61K38/46 ,  A61K38/48 ,  A61K47/48 ,  B32B5/16

CPC分类号： A61K47/482 ,  A61K47/48876 ,  A61K9/0024 ,  Y10S514/80 ,  Y10S514/806 ,  Y10S514/807 ,  Y10S514/808 ,  Y10S514/809 ,  Y10S514/963 ,  Y10T428/2989

摘要： This invention relates to novel salts composed of a cation derived from a peptide containing at least one basic group and an anion derived from a carboxy-terminated polyester, processes for the manufacture of such salts, and the use of such salts in the manufacture of extended release pharmaceutical compositions. The salts of the invention possess a variety of properties which are useful in the formulation of extended release pharmaceutical compositions, whether the salts are in pure form or are in admixture with either an excess of the peptide in its free, unbound form or an excess of the free polyester.

公开(公告)号：US3962370A

公开(公告)日：1976-06-08

申请号：US506778

申请日：1974-09-17

申请人： Francis Gowland Hutchinson

发明人： Francis Gowland Hutchinson

IPC分类号： C08F291/00 ,  C08G18/63 ,  C08L57/00 ,  C08L75/04

CPC分类号： C08F291/00 ,  C08G18/637 ,  C08L57/00 ,  C08L75/04

摘要： A shaped polymeric article comprising from 1% to 60% by weight, preferably from 5% to 30% by weight of a cross-linked polymeric material having a glass-rubber transition temperature of not more than 25.degree.C and from 99% to 40% by weight, preferably from 95% to 70% by weight, of a vinyl polymer, in which the cross-linked polymeric material is formed from precursors therefor comprising at least one polymer, having a glass-rubber transition temperature of not more than 25.degree.C, at least 80% by weight of said polymer having a molecular weight of at least 3000, and preferably consisting of at least one polymer having a glass-rubber transition temperature of not more than 25.degree.C and a molecular weight of at least 3000, and at least on cross-linking agent reactive with said polymer.

摘要翻译： 一种成型的聚合物制品，其包含1重量％至60重量％，优选5重量％至30重量％的玻璃 - 橡胶转变温度不超过25℃和99％至40％的交联聚合物材料 重量百分比，优选95％至70％的乙烯基聚合物，其中交联聚合物材料由其前体形成，其包含至少一种聚合物，其玻璃 - 橡胶转变温度不超过25 至少80重量％的分子量为至少3000的所述聚合物，并且优选由玻璃 - 橡胶转变温度不超过25℃至少分子量至少为一个的至少一种聚合物组成 3000，并且至少在与所述聚合物反应的交联剂上。

公开(公告)号：US6034175A

公开(公告)日：2000-03-07

申请号：US235270

申请日：1999-01-22

申请人： Francis Gowland Hutchinson

发明人： Francis Gowland Hutchinson

IPC分类号： A61K9/107 ,  A61K9/00 ,  A61K9/16 ,  A61K9/22 ,  A61K9/52 ,  A61K38/00 ,  A61K38/04 ,  A61K38/11 ,  A61K38/17 ,  A61K38/21 ,  A61K38/22 ,  A61K38/23 ,  A61K38/24 ,  A61K38/26 ,  A61K38/28 ,  A61K38/35 ,  A61K38/43 ,  A61K38/46 ,  A61K38/48 ,  A61K47/48 ,  B32B5/16

CPC分类号： A61K47/482 ,  A61K47/48876 ,  A61K9/0024 ,  Y10S514/80 ,  Y10S514/806 ,  Y10S514/807 ,  Y10S514/808 ,  Y10S514/809 ,  Y10S514/963 ,  Y10T428/2989

摘要： This invention relates to novel salts composed of a cation derived from a peptide containing at least one basic group and an anion derived from a carboxy-terminated polyester, processes for the manufacture of such salts, and the use of such salts in the manufacture of extended release pharmaceutical compositions. The salts of the invention possess a variety of properties which are useful in the formulation of extended release pharmaceutical compositions, whether the salts are in pure form or are in admixture with either an excess of the peptide in its free, unbound form or an excess of the free polyester.

公开(公告)号：US3932555A

公开(公告)日：1976-01-13

申请号：US379315

申请日：1973-07-16

申请人： John Eric Goodrich ,  Francis Gowland Hutchinson

发明人： John Eric Goodrich ,  Francis Gowland Hutchinson

IPC分类号： C08F2/00 ,  C08F283/12 ,  C08L83/04 ,  C08G77/42 ,  C08G77/38

CPC分类号： C08L83/04 ,  C08G77/02 ,  C08G77/12 ,  C08G77/16 ,  Y10S525/912 ,  Y10S525/925

摘要： A reinforced silicone elastomer formed from 95% to 20% by weight of a cross-linkable poly(organo siloxane) and from 5% to 80% by weight of a polymerisable ethylenically unsaturated material by cross-linking a substantial proportion of the poly(organosiloxane) before a substantial proportion of the ethylenically unsaturated material is polymerised, the ethylenically unsaturated material subsequently being polymerised.

摘要翻译： 通过交联相当比例的聚（有机硅氧烷）形成的95％-20％重量的可交联聚（有机硅氧烷）和5％至80％重量的可聚合烯属不饱和材料的增强硅氧烷弹性体 ），然后将烯键式不饱和材料的相当比例聚合，随后将烯属不饱和材料聚合。