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    Antibacterial compositions containing a 4-amino-pyrimido-(4,5,b)-quinoxaline-5,10-dioxide and method of using same
    1.
    发明授权
    Antibacterial compositions containing a 4-amino-pyrimido-(4,5,b)-quinoxaline-5,10-dioxide and method of using same 失效
    含有4-氨基 - 嘧啶并 - （4,5，b） - 喹喔啉-5,10-二氧化物的抗菌组合物及其使用方法

    公开(公告)号：US3985879A

    公开(公告)日：1976-10-12

    申请号：US511175

    申请日：1974-10-02

    申请人： Florin Seng ,  Kurt Ley ,  Karl Georg Metzger

    发明人： Florin Seng ,  Kurt Ley ,  Karl Georg Metzger

    IPC分类号： A23K1/16 ,  A61K31/505

    CPC分类号： A23K20/116

    摘要： 4-amino-pyrimido-(4,5,b)-quinoxaline-5,10-dioxides of the formula: ##SPC1##WhereinR is hydrogen, a straight or branched chain saturated or partially unsaturated substituted or unsubstituted aliphatic moiety or a substituted or unsubstituted cycloaliphatic moiety, are produced by reacting quinoxaline-di-N-oxide of the formula: ##SPC2##With an amine of the general formula R--NH.sub.2, wherein R is as defined, above, in a diluent, at a temperature in the range of 20.degree. to 100.degree. C.These compounds are useful for their antimicrobial activity. They exhibit activity against both gram positive and gram negative bacteria.

    摘要翻译： 4-氨基 - 嘧啶并 - （4,5，b） - 喹喔啉-5,10-二氧化物，其结构如下：

    Antibacterial benzo-1,2,4-triazines
    2.
    发明授权
    Antibacterial benzo-1,2,4-triazines 失效
    抗菌苯并-1,2,4-三嗪

    公开(公告)号：US4027022A

    公开(公告)日：1977-05-31

    申请号：US602109

    申请日：1975-08-05

    申请人： Florin Seng ,  Kurt Ley ,  Karl Georg Metzger

    发明人： Florin Seng ,  Kurt Ley ,  Karl Georg Metzger

    IPC分类号： A23K1/16 ,  A61K31/53

    CPC分类号： A23K20/116

    摘要： Antimicrobial compositions and uses employing benzo-1,2,4-triazines-1,4-di-N-oxides substituted in the 3-position with a substituted amino group and optionally substituted in the benzo ring are described. The compounds utilized, of which 3-(N-acetoacetylamino)benzo-1,2,4-triazine-1,4-di-N-oxide is a typical embodiment, are prepared from the corresponding 2-aminobenzo-1,2,4-triazine-1,4-di-N-oxide through alkylation or acylation.

    摘要翻译： 描述了在3-位被取代的氨基取代并任选被苯并环取代的苯并1,2,4-三嗪-1,4-二-N-氧化物的抗微生物组合物和用途。 使用其中的3-（N-乙酰乙酰基氨基）苯并-1,2,4-三嗪-1,4-二-N-氧化物的典型实施方案由相应的2-氨基苯并-1,2- 通过烷基化或酰化形成4-三嗪-1,4-二-N-氧化物。

    Benzo-1,2,4-triazines
    3.
    发明授权
    Benzo-1,2,4-triazines 失效
    苯并-1,2,4-三唑

    公开(公告)号：US3957779A

    公开(公告)日：1976-05-18

    申请号：US413887

    申请日：1973-11-08

    申请人： Florin Seng ,  Kurt Ley ,  Karl Georg Metzger

    发明人： Florin Seng ,  Kurt Ley ,  Karl Georg Metzger

    IPC分类号： A23K1/16 ,  C07D253/08

    CPC分类号： A23K20/116

    摘要： Benzo-1,2,4-triazines-1,4-di-N-oxides substituted in the 3-position with a substituted amino group and optionally substituted in the benzo ring are antimicrobial agents. The compounds, of which 3-(N-acetoacetylamino)benzo-1,2,4-triazine-1,4-di-N-oxide is a typical embodiment, are prepared from the corresponding 2-aminobenzo-1,2,4-triazine-1,4-di-N-oxide through alkylation or acylation.

    Animal fodder compositions containing a 4-amino-pyrimido-( 4,5,b)-quinoxaline-5,10-dioxide and method of using same
    5.
    发明授权
    Animal fodder compositions containing a 4-amino-pyrimido-( 4,5,b)-quinoxaline-5,10-dioxide and method of using same 失效
    含有4-氨基 - 嘧啶并（4,5，b） - 喹喔啉-5,10-二氧化物的动物饲料组合物及其使用方法

    公开(公告)号：US3984554A

    公开(公告)日：1976-10-05

    申请号：US546403

    申请日：1975-02-03

    申请人： Florin Seng ,  Kurt Ley ,  Karl Georg Metzger

    发明人： Florin Seng ,  Kurt Ley ,  Karl Georg Metzger

    IPC分类号： A23K1/16 ,  A61K31/505

    CPC分类号： A23K20/116

    摘要： 4-amino-pyrimido-(4,5,b)-quinoxaline-5,10-dioxides of the formula: ##SPC1##WhereinR is hydrogen, a straight or branched chain saturated or partially unsaturated substituted or unsubstituted aliphatic moiety or a substituted or unsubstituted cycloaliphatic moiety, are produced by reacting quinoxaline-di-N-oxide of the formula: ##SPC2##With an amine of the general formula R-NH.sub.2, wherein R is as defined, above, in a diluent, at a temperature in the range of 20.degree. to 100.degree. C.These compounds are useful for their antimicrobial activity. They exhibit activity against both gram positive and gram negative bacteria.

    摘要翻译： 4-氨基 - 嘧啶并 - （4,5，b） - 喹喔啉-5,10-二氧化物，其结构如下：

    Veterinary feedstuffs
    6.
    发明授权
    Veterinary feedstuffs 失效
    兽用饲料

    公开(公告)号：US3984553A

    公开(公告)日：1976-10-05

    申请号：US563084

    申请日：1975-03-28

    申请人： Florin Seng ,  Kurt Ley ,  Karl Georg Metzger

    发明人： Florin Seng ,  Kurt Ley ,  Karl Georg Metzger

    IPC分类号： C07D241/52 ,  C07D277/18 ,  C07D491/04 ,  A61K31/495

    CPC分类号： C07D277/18 ,  C07D241/52 ,  C07D491/04

    摘要： Imines of 2-formylquinoxaline-3-carboxylic acid-1,4-dioxides and their salts are obtained through treatment of the lactone or a salt of 2-hydroxymethylquinoxaline-N,N-dioxide-3-carboxylic acid with a reactant bearing a free primary amino group. Veterinary feedstuffs are produced by combining a nutritious material with an imine as above described.

    摘要翻译： 通过用含有游离的反应物的内酯或2-羟甲基喹喔啉-N，N-二甲基-3-羧酸的盐处理2-甲酰基喹喔啉-3-羧酸-1,4-二氧化物及其盐， 伯氨基。 通过将营养物质与如上所述的亚胺组合来生产兽药饲料。